Results 131 to 140 of about 7,164 (304)
Killing Vector Fields of Invariant Metrics on Five-Dimensional Solvable Lie Groups
MathematicsIn this paper we study the existence of Killing vector fields for right-invariant metrics on five-dimensional Lie groups. We begin by providing some explanation of the classification lists of the low-dimensional Lie algebras.
Gerard Thompson
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Inseparable finite solvable groups. II
, 1977 A finite group is called inseparable if the only normal subgroups over which it splits are the group itself and the trivial subgroup. Let E be the formation of finite solvable groups with elementary abelian Sylow subgroups. This note establishes the fact
Homer Bechtell
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
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From homogeneous metric spaces to Lie groups
Comptes Rendus. MathématiqueWe study homogeneous metric spaces, by which we mean connected, locally compact metric spaces whose isometry group acts transitively.After a review of a number of classical results, we use the Gleason–Iwasawa–Montgomery–Yamabe–Zippin structure theory to ...
Cowling, Michael G. +4 more
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Non-linear, solvable, residually $p$ groups
, 2023 In 2005, Borisov and Sapir proved that ascending HNN extensions of finitely generated linear groups are residually finite. Subsequently, Dru\c{t}u and Sapir noted the existence of finitely generated non-linear residually finite groups based on the work ...
Lee, Donsung
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Packing subgroups in solvable groups
, 2014 We show that any subgroup of a (virtually) nilpotent-by-polycyclic group satisfies the bounded packing property of Hruska-Wise. In particular, the same is true about metabelian groups and linear solvable groups.
Sardar, Pranab
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