Results 121 to 130 of about 15,691 (309)
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Assessing Solvate Prediction Approaches: A Case of Spironolactone [PDF]
In silico methods for predicting solvate formation can guide and simplify solid form screening and solvent selection in crystallization processes. Solvates involve many complicated nonspecific interactions, making solvate prediction challenging.
Ling Zhou (51948) +5 more
core +1 more source
Chlorothiazide formic acid solvate (1/2) [PDF]
, 2007 Chlorothiazide forms a 1:2 solvate with formic acid (systematic name: 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide methanoic acid disolvate), C7H6ClN3O4S2·2CH2O2.
Johnston, Andrea +2 more
core +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Investigations of Streptomyces coelicolor A3(2) siderophore binding proteins [PDF]
Siderophores are small, high-affinity ferric iron chelators released by many microorganisms and some plants to solubilize iron. They are of great interest due to their clinical use to treat iron overload in humans, and also in relation to the development
Patel, Prakash
core
Study on glyme-based lithium solvate ionic liquids: fundamental properties and application to rechargeable lithium batteries [PDF]
, 2014 横浜国立大学博士（学術）Solvate ionic liquids are a new class of room-temperature ionic liquids (ILs) in which ligandmolecules, as a third component of the liquids, strongly solvate the cations and/or anions ofsalts to form solvate complex ions.
21785, 張, 策
core
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Rimonabant 2-methoxyethanol solvate and method for preparing same [PDF]
, 2007 The invention relates to a rimonabant 2-methoxyethanol solvate, and to a method for preparing the same ...
Coquerel, Gérard, Fours, Baptiste
core