Results 21 to 30 of about 65,658 (300)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Legal regulation of insurance companies' solvency in the EU: Solvency II [PDF]

open access: yesMegatrend Revija, 2018
The improvement of science and practice of risk management, the development of the insurance market, an increasing importance of the insurance industry and the introduction of Basel II regulations in the banking industry, have led to the development of ...
Njegomir Vladimir, Petrović Zdravko
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

SOLVENCY II – THE NEW EU SOLVENCY REGIME ON THE INSURANCE MARKET [PDF]

open access: yesBuletin ştiinţific: Universitatea din Piteşti. Seria Ştiinţe Economice, 2012
The main causes that lead to insurer’s solvency issues such as the underwriting, investment or reinsurance deficiencies have remained the same over time. However, their incidence is increasing, as well as their complexity.
Emilia CLIPICI
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Quantitative Market Risk Assessment for Insurance Companies

open access: yesФинансы: теория и практика, 2022
The business strategy, the underwriting policy, the investment strategy of insurance companies and some external factors influence their ability to meet liabilities.
E. V. Aldukhova
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

THE IMPACT OF TRANSITION FROM SOLVENCY I TO SOLVENCY II OVER THE PREMIUM RESERVES IN GENERAL INSURANCE [PDF]

open access: yesEconomica, 2020
One of the most important purposes of any insurance company is to be solvable. The technical reserve represents the main part of the obligations of an insurance company, thus the correct evaluation of this item is primordial.
Oleg VEREJAN, Victor CALDARE
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

SOLVENCY II

open access: yesIustinianus Primus Law Review, 2014
The main purpose of this paper is to analyze Solvency II which is a new supranational insurance regulatory regime introduced by the institutions of the European Union in order to enhance the financial stability of the insurance and reinsurance ...
Biljana Petrevska
doaj  

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