Results 31 to 40 of about 6,101,568 (282)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Solvency II approach to the risk management in commercial insurance companies
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2010 In the year 2001, the European Comission started to revise the legislation Solvency I and to implement a new approach called Solvency II. The regulation called Solvency II is based on regulation considering management of risks of commercial insurance ...
Eva Vávrová
doaj +1 more source
The dangers associated with Solvency II’s imitation of Basel II [PDF]
Journal of Business Strategy Finance and Management, 2019 Ten years have passed after the last financial and economic crisis. As such, it is a good time to assess and to be reminded of the lessons that were learned and, more importantly, the lessons that were not learned, when it comes to the post-crisis reform of EU’s financial regulatory system.
Kristina Loguinova, Koen Byttebier
openaire +2 more sources
Risk aggregation in Solvency II: How to converge the approaches of the internal models and those of the standard formula? [PDF]
Two approaches may be considered in order to determine the Solvency II economic capital: the use of a standard formula or the use of an internal model (global or partial).
Stéphane Loisel, Laurent Devineau
core +2 more sources
THE IMPACT OF TRANSITION FROM SOLVENCY I TO SOLVENCY II OVER THE PREMIUM RESERVES IN GENERAL INSURANCE [PDF]
Economica, 2020 One of the most important purposes of any insurance company is to be solvable. The technical reserve represents the main part of the obligations of an insurance company, thus the correct evaluation of this item is primordial.
Oleg VEREJAN, Victor CALDARE
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Solventnost II in holistično obvladovanje tveganj
Economic and Business Review, 2017 The Solvency II Directive poses a major challenge to insurance companies, fundamentally changing the way they currently do business. In the study, we examined the qualitative requirements of the so-called second pillar, namely the role, importance and ...
Helena Bešter
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source