Results 51 to 60 of about 65,658 (300)
Machine Learning in Least-Squares Monte Carlo Proxy Modeling of Life Insurance Companies
Risks, 2020 Under the Solvency II regime, life insurance companies are asked to derive their solvency capital requirements from the full loss distributions over the coming year.
Anne-Sophie Krah +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
De rentecurve voor de waardering van langetermijngaranties op de Solvency II-balans [PDF]
MAB, 2014 Vanaf 2016 geldt een nieuw toezichtskader voor verzekeraars opererend binnen de Europese Unie, genaamd Solvency II. In dit toezichtskader staan marktwaarden en risico’s centraal, waardoor meer kapitaal aangehouden moet worden voor risicovolle producten ...
Paul van Ammelrooij
doaj +3 more sources
Biztosítási és pénzügyi kockázat együttes hatása a biztosítók szolvencia-számításánál (Common effect of insurance and financial risk in the solvency calculation of insurers) [PDF]
, 2010 A Szolvencia II néven említett új irányelv elfogadása az Európai Unióban új helyzetet teremt a biztosítók tőkeszükséglet-számításánál. A tanulmány a biztosítók működését modellezve azt elemzi, hogyan hatnak a biztosítók állományának egyes jellemzői a ...
Szüle, Borbála
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Ryzyko zakładów ubezpieczeń w świetle nowych wymogów kapitałowych Solvency II
Problemy Zarządzania, 2013 The aim of this work is to conduct the key aspects of a heated debate about effects and issues connected with implementing a new solution of risk management in insurance companies included in Solvency II.
Teresa Czerwińska
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Assessment of the Stability of Insurance Companies: The Case of Baltic Non-Life Insurance Market
Economics and Business, 2018 The study gives an overview of the Baltic non-life insurance market. The purpose of the research is to summarise stability statistics on solvency ratios, risk profiles and capital surplus, which was contained in Solvency and Financial Condition reports ...
Zariņa Ilze +2 more
doaj +1 more source
In this paper we discuss some issues proposed in the Solvency II - QIS3 report. In particular we comment and discuss the \AISAM-ACME study on non-life long tail liabilities; reserve risk and risk margin assessment under Solvency II".
Dhaene, Jan +2 more
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