Results 71 to 80 of about 4,208 (295)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Capital Requirements for aggregate risks in longterm living products: a stochastic approach

, 2010
Referring to the Solvency II regulation, aim of the paper is to obtain an estimate for the Solvency Capital Requirement of a life annuity portfolio when stochastic interest and mortality rates are considered.
A. Orlando, COPPOLA, MARIAROSARIA, POLITANO, MASSIMILIANO   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

La disciplina Solvency II

, 2022
Il presente capitolo offre una panoramica dei principali cambiamenti nella concreta operatività di una compagnia di assicurazione alla luce della introduzione della cornice regolamentare "Solvency II".This chapter aims to provide an overview of the main
Gatti Giuseppe, Nicotera Rosa, Tosti Alberto, Bracci Daniele, Santoboni Fabrizio   +4 more
core  

Solvency II Impact on the Romanian Insurance Industry [PDF]

Ovidius University Annals: Economic Sciences Series, 2019
The article provides a quantitative evaluation in which is investigated the impact of the Solvency II on the Romanian insurance industry after three years of the implementation of the new insurance regulatory framework.
Aurora Elena Dina (Manolache)
doaj  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Solvency requirements for life annuities allowing for mortality risks: internal models versus standard formulas

, 2009
Tools for the management of risks inherent in a life annuity portfolio are briefly presented following the approach suggested by risk management principles.
OLIVIERI A, PITACCO, ERMANNO
core  

Investment Portfolio Allocation and Insurance Solvency: New Evidence from Insurance Groups in the Era of Solvency II

Risks
This study examines the effect of the investment portfolio structure on insurers’ solvency, as measured by the Solvency Capital Requirement ratio.
Thomas Poufinas, Evangelia Siopi
doaj   +1 more source

Earthquake insurance in Iran: solvency of local insurers in light of current market practices [PDF]

Natural Hazards and Earth System Sciences
Owing to its geographical position within one of the most seismically active zones globally, Iran has experienced numerous historically impactful earthquakes.
M. Ghafory-Ashtiany, H. Motamed
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source