Results 81 to 90 of about 65,658 (300)

A Dynamic Solvency Approach for Life Insurance [PDF]

The paper investigates risk management processes in life insurance, in a perspective consistent with the framework of Solvency II. The paper starts with the breakdown of the business dynamics.
Cocozza, Rosa, Di Lorenzo, Emilia
core   +1 more source

Optimales Anlagevermögen von Versicherungsunternehmen [PDF]

, 2014
Versicherungsunternehmen (VU) unterliegen detaillierten regulatorischen Vorschriften und werden in besonderem Maße behördlich beaufsichtigt. Gegenwärtig erfolgt die Einführung einheitlicher europäischer Regulierungsvorschriften im Rahmen des Projekts ...
Kaposty, Florian, Pelster, Matthias
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

RecessionRisk⁺: A Novel Recession Risk Model with Applications to the Solvency II Framework and Recession Crises Forecasting

Mathematics
The Solvency II regulatory framework requires European insurance companies to guarantee their solvability and stability by retaining enough Own Funds to cover future unexpected losses at a given confidence level.
Jacopo Giacomelli, Luca Passalacqua
doaj   +1 more source

Earthquake insurance in Iran: solvency of local insurers in light of current market practices [PDF]

Natural Hazards and Earth System Sciences
Owing to its geographical position within one of the most seismically active zones globally, Iran has experienced numerous historically impactful earthquakes.
M. Ghafory-Ashtiany, H. Motamed
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Risk measures versus ruin theory for the calculation of solvency capital for long-term life insurances

Dependence Modeling, 2016
The purpose of this paper is twofold. First we consider a ruin theory approach along with risk measures in order to determine the solvency capital of long-term guarantees such as life insurances or pension products.
Devolder Pierre, Lebègue Adrien
doaj   +1 more source

On Finite-Time Ruin Probabilities for Classical Risk Models [PDF]

This paper is concerned with the problem of ruin in the classical compound binomial and compound Poisson risk models. Our primary purpose is to extend to those models an exact formula derived by Picard and Lefèvre (1997) for the probability of (non-)ruin
Claude Lefèvre, Stéphane Loisel
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Effects of Traditional Reinsurance on Demographic Risk Under the Solvency II Framework

Risks
This paper investigates the role of proportional reinsurance as a practical and flexible tool for managing demographic risk in life insurance, with a focus on its impact on both the Solvency Capital Requirement (SCR) and expected profitability.
Emily Bianchessi, Gian Paolo Clemente, Francesco Della Corte, Nino Savelli   +3 more
doaj   +1 more source