Results 181 to 190 of about 1,723,808 (348)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Analyzing the Solvent Effects in Palladium/<i>N</i>-Heterocyclic Carbene (Pd/NHC)-Catalyzed Suzuki-Miyaura Coupling of Aryl Chlorides: A Computational Study of the Oxidative Addition Step with Experimental Validation. [PDF]

J Phys Chem B
Collier M, Rodriguez B, Lasiter S, Olmsted AD, Simmons EK, Boyce GR, Lambrecht DS.   +6 more
europepmc   +1 more source

Repurposing orange peel waste for limonene extraction using deep eutectic solvents for cosmetic applications

Monika Arnič, Kristina Andrejc, Mónia A.R. Martins, Filipe H.B. Sosa, João A.P. Coutinho, Blaž Likozar, Filipa A. Vicente   +6 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Application of the solvent effect on bioluminescent reporter bacteria as a real-time membrane toxicity assay. [PDF]

Access Microbiol
Myer PR, Turco RF, Applegate BM.
europepmc   +1 more source

A smoothly decoupled particle interface: New methods for coupling explicit and implicit solvent [PDF]

, 2011
Jason A. Wagoner, Vijay S. Pande
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Comparative evaluation of ultrasound-assisted extraction and micelle-mediated extraction of bioactive compound from Acmella oleracea. [PDF]

Sci Rep
Suktham K, Surassmo S, Thiramanas R, Yahya A, Chansriniyom C, Polpanich D, Asawapirom U.   +6 more
europepmc   +1 more source

Decoding the aroma of Jägermeister liqueur through sensory-directed flavor analysis combined with solvent-assisted flavor evaporation and headspace-stir bar sorptive extraction

Lin Zhu, Zexin Lin, Yong‐Fei Zheng, Jiaqi Liang, Yan‐Jun Li, S. Kramp, Youfeng Zhang, Can Xiang, L Chen, Marina Rigling, Lea Hannemann, Claudia Oellig, Yanyan Zhang   +12 more
openalex   +1 more source

Solvent Annealing of Perovskite‐Induced Crystal Growth for Photovoltaic‐Device Efficiency Enhancement

Advances in Materials, 2014
Zhengguo Xiao, Qingfeng Dong, Cheng Bi, Yuchuan Shao, Yong-bo Yuan, Jinsong Huang   +5 more
semanticscholar   +1 more source