Results 171 to 180 of about 9,903,999 (366)

Solvent Effects on the Conformational Preferences of 2,6-Pyridylcarboxamide Foldamers. [PDF]

open access: yesChemistry
Davis AR   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Charge and Solvent Effects on the Redox Behavior of Vanadyl Salen-Crown Complexes. [PDF]

open access: yesJ Phys Chem A, 2023
Nguyen HM   +6 more
europepmc   +1 more source

A THEORETICAL INVESTIGATION OF NITROBENZENE HYDROGENATION: GASPHASE, SOLVENT EFFECTS, AND Pd CATALYSIS [PDF]

open access: bronze
Ayad Fadhil Alkaim   +5 more
openalex   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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