Results 41 to 50 of about 257,523 (289)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Correlating physico-chemical properties of analytes with Hansen solubility parameters of solvents using machine learning algorithm for predicting suitable extraction solvent

open access: yesScientific Reports
Artificial neural networks (ANNs) are biologically inspired algorithms designed to simulate the way in which the human brain processes information. In sample preparation for bioanalysis, liquid–liquid extraction (LLE) represents an important step with ...
Eman A. Mostafa   +8 more
doaj   +1 more source

Determining an Efficient Solvent Extraction Parameters for Re-Refining of Waste Lubricating Oils [PDF]

open access: yesMehran University Research Journal of Engineering and Technology, 2012
Re-refining of vehicle waste lubricating oil by solvent extraction is one of the efficient and cheapest methods. Three extracting solvents MEK (Methyl-Ethyl-Ketone), 1-butanol, 2-propanol were determined experimentally for their performance based on ...
Hassan Ali Durrani   +2 more
doaj  

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Viscosity Index Improvement of Lubricating Oil Fraction (SAE – 30)

open access: yesIraqi Journal of Chemical and Petroleum Engineering, 2008
An investigation was conducted for the improvement of viscosity index of a lubricating oil fraction (SAE – 30) obtained from vacuum distillation unit of lube oil plant of Daura Refinery, using solvent extraction process.
Abdul-Halim Abdul-Karim Mohammed   +1 more
doaj  

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media [PDF]

open access: yesChemical and Biochemical Engineering Quarterly, 2018
Deep eutectic solvent (DES)/water mixture as alternative extraction solvent was proposed for the efficient extraction of Ginkgo flavonoids from Ginkgo biloba leaves.
M. Yang, J. Cao, F. Cao, C. Lu, E. Su
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

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