Results 71 to 80 of about 670,141 (365)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Correlating physico-chemical properties of analytes with Hansen solubility parameters of solvents using machine learning algorithm for predicting suitable extraction solvent

Scientific Reports
Artificial neural networks (ANNs) are biologically inspired algorithms designed to simulate the way in which the human brain processes information. In sample preparation for bioanalysis, liquid–liquid extraction (LLE) represents an important step with ...
Eman A. Mostafa, Mohammad Abdul Azim, Asmaa A. ElZaher, Ehab F. ElKady, Marwa A. Fouad, Fatma H. Ghazy, Esraa A. Radi, Mahmoud Abo El Makarim Saleh, Ahmed M. El Kerdawy   +8 more
doaj   +1 more source

Extraction Techniques for Polycyclic Aromatic Hydrocarbons in Soils

International Journal of Analytical Chemistry, 2010
This paper aims to provide a review of the analytical extraction techniques for polycyclic aromatic hydrocarbons (PAHs) in soils. The extraction technologies described here include Soxhlet extraction, ultrasonic and mechanical agitation, accelerated ...
E. V. Lau, S. Gan, H. K. Ng
doaj   +1 more source

Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media [PDF]

Chemical and Biochemical Engineering Quarterly, 2018
Deep eutectic solvent (DES)/water mixture as alternative extraction solvent was proposed for the efficient extraction of Ginkgo flavonoids from Ginkgo biloba leaves.
M. Yang, J. Cao, F. Cao, C. Lu, E. Su
doaj   +1 more source

Computing three-dimensional densities from force densities improves statistical efficiency [PDF]

J. Chem. Phys. 151 (2019) 064124, 2019
The extraction of inhomogeneous 3-dimensional densities around tagged solutes from molecular simulations is known to have a very high computational cost because this is traditionally performed by collecting histograms, with each discrete voxel in three-dimensional space needing to be visited significantly. This paper presents an extension of a previous
arxiv   +1 more source

Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction-stir bar sorptive extraction-derivatization and gas chromatography-mass spectrometry [PDF]

, 2013
This work describes the development, optimiza- tion, and validation of a new method for the simultaneous determination of a wide range of pharmaceuticals (beta- blockers, lipid regulators ...
A Azzouz, A Cottell, A Göbel, A Peck, A Saleh, A Shrivastava, ARM Silva, E Baltussen, E Concha-Graña, E Pérez-Carrera, Eduardo González-Mazo, F Pomati, FJ Camino-Sánchez, J Xu, JB Quintana, JC Durán-Alvarez, KJ Bisceglia, M Kawaguchi, M Kuster, M Petrovic, M Winkler, Marina G. Pintado-Herrera, MG Cantwell, MJ Gomez, N Jonkers, N Ramírez, PA Lara-Martín, PA Lara-Martín, Pablo A. Lara-Martín, R Rodil, SB Hawthorne, SL Rice, T Kupper, VM León, WM Liu, Y Valcarcel   +35 more
core   +2 more sources

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Why solvent response contributions to solvation free energies are compatible with Ben-Naim's theorem [PDF]

arXiv, 2023
We resolve a seeming paradox arising from a common misinterpretation of Ben-Naim's theorem, which rests on a pairwise decomposition of the Hamiltonian of a molecular solute/solvent system into pairwise solute-solvent and solvent-solvent interactions. According to this theorem, also the solvation entropy can be decomposed into a solute-solute term and a
arxiv  

Effect of extraction methods on physicochemical, nutritional, antinutritional, antioxidant and antimicrobial activity of Moringa (Moringa oleifera Lam.) seed kernel oil [PDF]

, 2018
The effect of three different extraction methods, namely supercritical CO2, soxhlet and solvent methods on the yield, efficiency, physico-chemical properties, nutritional, anti-nutritional composition, antimicrobial and antioxidant activities of moringa (
Dinesha, B. L., Naik, Nagaraj, Nidoni, Udaykumar, Ramachandra, C. T., Sankalpa, K.B.   +4 more
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source