Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
THE EXTRACTION OF MORPHINE WITH IMMISCIBLE SOLVENTS. [PDF]
Journal of the American Chemical Society, 1901 n ...
openaire +1 more source
Optimisation of pressurized liquid extraction using a multivariate chemometric approach for the determination of anticancer drugs in sludge by ultra high performance liquid chromatography–tandem mass spectrometry [PDF]
, 2013 The present paper describes an analytical method for the determination of 2 widely administered anticancer drugs, ifosfamide and cyclophosphamide, contained in sewage sludge. The method relies on the extraction from the solid matrix by pressurized liquid
Albasi, Claire +5 more
core +4 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Kinetics and thermodynamics of cottonseed oil extraction
Grasas y Aceites, 2011 Petroleum derived n-hexane is commercially used in solvent extraction plants due to its higher extraction efficiency in spite of the fact that it is graded as highly toxic and hazardous.
Devesh K. Saxena +2 more
doaj +1 more source
Dispersive liquid-liquid microextraction-gas chromatography-mass spectrometric determination of polycylic aromatic hydrocarbons in water [PDF]
, 2011 In this work, a sample preparation method based on dispersive liquid-liquid microextraction (DLLME) coupled with gas chromatography-mass spectrometry (GC-MS) was developed for the extraction of polycyclic aromatic hydrocarbons (PAHs), namely phenanthrene
Sharef A., Sarra Younes
core
Co-reduction of aluminium and lanthanide ions in molten fluorides : application to cerium and samarium extraction from nuclear waste [PDF]
, 2009 This work concerns the method of co-reduction process with aluminium ions in LiF–CaF2 medium (79–21 mol.%) on tungsten electrode for cerium and samarium extraction.
Chamelot, Pierre +3 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Chromatography OpenThe thermodynamic contribution to extraction of medical devices by organic solvents as a first sample preparation step in chemical characterization studies is evaluated by Abraham's solvation parameter model using five representative materials (low ...
Jianwei Li
doaj +1 more source
Prospectiva, 2015 Microalgae have the potential to produce a big amount of biodiesel per area unit owing to its high lipid content. However, for a sustainable biodiesel production from microalgae, the concept of biorefinery must be taken into account; this concept can be ...
Ángel Darío González-Delgado +1 more
doaj +1 more source