Results 121 to 130 of about 1,059,060 (337)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Formation of Racemic Phases of Amino Acids by Liquid-Assisted Resonant Acoustic Mixing Monitored by Solid-State NMR Spectroscopy

Molecules
Mechanochemistry has become a fundamental method in various sciences including biology and chemistry. Despite its popularity, the mechanisms behind mechanochemically induced reactions are not very well understood.
Leeroy Hendrickx, Calogero Quaranta, Emilian Fuchs, Maksim Plekhanov, Mirijam Zobel, Carsten Bolm, Thomas Wiegand   +6 more
doaj   +1 more source

The Behavior of Colloidal Suspensions with Immiscible Solvents [PDF]

, 1908
Walter L. Miller, Ryan McPherson
openalex   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

A Grape-Derived Solvent for the Recovery of Phenolic Compounds from Food Waste By-Products Using Ultrasonic-Assisted and Overnight Extraction

Molecules
This present study aimed to investigate the recovery of polyphenols from red onion peel (OPP) and pomace of Merlot (MWP) and Syrah (SWP) grape varieties, using a common biphasic solvent (70/30 ethanol/water) and a new biphasic and eco-friendly solvent ...
Dimitrios G. Lazaridis, Vassilios K. Karabagias, Nikolaos D. Andritsos, Aris E. Giannakas, Ioannis K. Karabagias   +4 more
doaj   +1 more source

Solubility and Specific Rotatory Power of Carbohydrates and Certain Organic Acids and Bases in Pyridine and Other Solvents [PDF]

, 1905
Joseph G. Holty
openalex   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Least Squares Computer Calculations of Equilibrium Constants from Solvent Extraction Data. [PDF]

, 1959
Jan Rydberg, James C. Sullivan, Peer Møller Jørgensen, Susanne Refn   +3 more
openalex   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Innovative Approaches to Extracting Phenolics from Echinacea purpurea: Maximizing Yield and Efficacy

Foods
People have long been interested in plants rich in secondary metabolites and have tried to isolate them outside the plants. Purple coneflower is a crucial medicinal plant, known for its broad spectrum of bioactive substances.
Mateja Senica, Gregor Mlinšek, Denis Rusjan, Maja Mikulic-Petkovsek   +3 more
doaj   +1 more source