Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Homogenizing solvation: a polarity-gradient strategy for extreme cryogenic batteries. [PDF]
Guo Z, Zhao Y, Titirici MM.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Temperature-triggered microfluidic fabrication of monodisperse organic particles <i>via</i> LCST-mediated phase transition. [PDF]
Tanita K +5 more
europepmc +1 more source
Recent Advances in Fluorine- and Silicon-Integrated Organic Solvent Nanofiltration Membranes for Non-Polar Solvent Separation. [PDF]
He S, Song W, Che R, Wang E, Li C, Su B.
europepmc +1 more source
Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent. [PDF]
Kushwaha P +6 more
europepmc +1 more source
Is solvent-based dissolution and precipitation an effective substrate pretreatment for the enzymatic depolymerisation of poly(ethylene terephthalate)? [PDF]
Wain B +6 more
europepmc +1 more source
Design of Gold Extraction Solvents Using Machine Learning Models. [PDF]
Tsunemi T, Oshima T, Yokota H, Kaneko H.
europepmc +1 more source

