Results 161 to 170 of about 33,566 (233)

Sphingosine‐1‐Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex

open access: yesGlia, Volume 74, Issue 8, August 2026.
Neuronal contact‐induced expression of S1PR1 in astrocytes is regulated by JAK‐STAT3 signaling. Astrocytic S1PR1 modulates cortical astrocyte morphogenesis. Astrocytic S1PR1 regulates astrocyte territorial overlap/tiling in a competition dependent manner.
Jean Patrick M. Gonzales   +9 more
wiley   +1 more source

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

open access: yesGlia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford   +14 more
wiley   +1 more source

Alzheimer's Protection by PLCγ2 Compacts Plaques, Redistributes Microglia, and Protects Synapses in AppNL‐G‐F Mice

open access: yesGlia, Volume 74, Issue 8, August 2026.
The Alzheimer's disease protective PLCG2 P522R variant protects against amyloid‐induced synapse loss independently of amyloid load, promotes increased plaque compaction, and is associated with enhanced microglial engagement with diffuse amyloid. ABSTRACT The Alzheimer's disease protective P522R PLCG2 coding variant (rs72824905) is downstream of TREM2 ...
Ryan J. Bevan   +9 more
wiley   +1 more source

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

open access: yesGlia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck   +4 more
wiley   +1 more source

Intranasal Delivery of Bacterial Extracellular Vesicles Enables RNA Cargo Entry Into the Brain. [PDF]

open access: yesJ Extracell Vesicles
Ha JY   +8 more
europepmc   +1 more source

Real‐Time, Inline Quantitative MRI Enabled by Scanner‐Integrated Machine Learning: A Proof of Principle With NODDI

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 2, Page 986-995, August 2026.
ABSTRACT Purpose The clinical feasibility and translation of many advanced quantitative MRI (qMRI) techniques are inhibited by their restriction to ‘research mode’, due to resource‐intensive, offline parameter estimation. This work aimed to achieve ‘clinical mode’ qMRI, by real‐time, inline parameter estimation with a trained neural network (NN) fully ...
Samuel Rot   +13 more
wiley   +1 more source

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