Results 171 to 180 of about 33,566 (233)

Spatial characterization of backpropagating action potential-evoked Ca²⁺ signals in human cortical layer 2/3 pyramidal neurons. [PDF]

Front Synaptic Neurosci
Szöts I, Tóth M, Ludányi C, Barzó P, Csajbók ÉA, Tamás G, Molnár G.   +6 more
europepmc   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source

Spatially targeted inhibitory rhythms differentially affect neuronal integration. [PDF]

Elife
Headley DB, Latimer B, Aberbach A, Nair SS.   +3 more
europepmc   +1 more source

Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner, Véronique Dehlinger, Patrick Rodriguez, Kerstin Fabbri, Yvan Varisco, Matteo Pigni, Alessandra Lovison, Lucas Münzenmaier, Kasia Piorkowska, Aline Fuchs, Nadine Ait‐Bouziad, Nicolas Fournier, Sandra Jepaul, Jérôme Molette, Emanuele Gabellieri, Vincent Darmency, Sonia Poli, Andrea Pfeifer, Marie Kosco‐Vilbois, Francesca Capotosti   +19 more
wiley   +1 more source

What sets the mutation rate of a cell type in an animal species? [PDF]

PLoS Biol
de Manuel M, Przeworski M, Spisak N, Stolyarova A.   +3 more
europepmc   +1 more source

Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1403-1413, July 2026.
Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Vascular Features of Gallbladder Lesions Using Microvascular Flow Imaging on Transabdominal Ultrasonography: A Retrospective Study. [PDF]

Diagnostics (Basel)
Miwa H, Oishi R, Sakai N, Soma R, Shibasaki K, Ishino Y, Tsunoda S, Endo K, Funaoka A, Suzuki Y, Tsuchiya H, Komiyama S, Morimoto M, Maeda S.   +13 more
europepmc   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

In the Caudal Pontine Reticular Nucleus, Kv1.1 Expression Is Soma Size Dependent and Invariant During Postnatal Development. [PDF]

J Comp Neurol
Peterle J, Wicke KD, Pätz-Warncke C, Felmy F.   +3 more
europepmc   +1 more source

The Role of Dendritic Spines in Water Exchange Measurements With Diffusion MRI: Double Diffusion Encoding and Free‐Waveform MRI

NMR in Biomedicine, Volume 39, Issue 7, July 2026.
Geometric water exchange in dendritic spines imparts a similar signature on diffusion‐MRI signals as permeative, transmembrane water exchange. Current diffusion MRI methods are non‐specific to geometric and permeative exchange. This work proposes a method to disentangle these two modes of exchange, yielding both more accurate estimates of permeative ...
Arthur Chakwizira, Kadir Şimşek, Filip Szczepankiewicz, Marco Palombo, Markus Nilsson   +4 more
wiley   +1 more source