Results 181 to 190 of about 363,529 (321)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Presence of Antigen-Binding Cells for Five Diverse Antigens at the Onset of Lymphoid Development: Lack of Evidence for Somatic Diversification during Ontogeny [PDF]

, 1974
Janet M. Decker, J Clarke, Linda M. Bradley, Alexander Miller, Eli E. Sercarz   +4 more
openalex   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment. [PDF]

Ibrain
Li X, Fang K, Wang F.
europepmc   +1 more source

A First Investigation into the Use of Differential Somatic Cell Count as a Predictor of Udder Health in Sheep. [PDF]

Animals (Basel), 2023
Tolone M, Mastrangelo S, Scatassa ML, Sardina MT, Riggio S, Moscarelli A, Sutera AM, Portolano B, Negrini R.   +8 more
europepmc   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

STUDIES ON SOMATIC CELL MUTATIONS

, 1976
Sadayuki Ban, Fumio Suzuki, Masakatsu Horikawa   +2 more
openalex   +2 more sources

VIABILITY OF HOMOZYGOUS DEFICIENCIES IN SOMATIC CELLS OF DROSOPHILA MELANOGASTER [PDF]

, 1979
Pedro Ripóll, Antonio Garcı́a-Bellido
openalex   +1 more source

A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming. [PDF]

Commun Biol
Gürhan G, Sevinç K, Aztekin C, Gayretli M, Yılmaz A, Yıldız AB, Ervatan EN, Morova T, Datlı E, Coleman OD, Kawamura A, Lack NA, Syed H, Önder T.   +13 more
europepmc   +1 more source

Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups. [PDF]

Int J Mol Sci, 2023
Nakamura S, Morohoshi K, Inada E, Sato Y, Watanabe S, Saitoh I, Sato M.   +6 more
europepmc   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source