Results 291 to 300 of about 363,529 (321)
Some of the next articles are maybe not open access.
Interaction of Sperm with Somatic Cells
Science, 1974We regret we did not cite the earlier work of our colleagues in the field of gynecology mentioned above; we disagree with their contention that the methods were put to the same use and achieved the same results. Our study dealt with nonphagocytic spermatozoal transfer of genetic information to cultured somatic cells. Coppleson and Reid regarded sperm
M. Coppleson, Beven L. Reid
openaire +3 more sources
Reprogramming mammalian somatic cells
Theriogenology, 2012Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits transformation of a somatic cell into an undifferentiated zygote with the potential to develop into a newborn animal (i.e., a clone). In somatic cells, chromatin is programmed to repress most genes and express some, depending on the tissue.
Nelida Rodriguez-Osorio +5 more
openaire +3 more sources
Reprogramming of Somatic Cells
2012Reprogramming of adult somatic cells into pluripotent stem cells may provide an attractive source of stem cells for regenerative medicine. It has emerged as an invaluable method for generating patient-specific stem cells of any cell lineage without the use of embryonic stem cells.
openaire +3 more sources
Reprogramming of somatic cells
2017Limited access to human neurons has posed a significant barrier to progress in biological and preclinical studies of the human nervous system. The advent of cell reprogramming technologies has widely disclosed unprecedented opportunities to generate renewable sources of human neural cells for disease modeling, drug discovery, and cell therapeutics ...
openaire +4 more sources
1982
Pathway Mutants in Mammalian Cells and their Contribution to the Analysis of Drug Resistance.- Isolation and Analysis of Chinese Hamster Cells Carrying Forward and Reverse Mutations in the Hypoxanthine-Guanine Phosphoribosyltransferase Locus.- Towards Mapping Genes to Chromosomes Using Two Dimensional Gel Electrophoresis of Proteins and Somatic Cell ...
C. Thomas Caskey, D. Christopher Robbins
openaire +2 more sources
Pathway Mutants in Mammalian Cells and their Contribution to the Analysis of Drug Resistance.- Isolation and Analysis of Chinese Hamster Cells Carrying Forward and Reverse Mutations in the Hypoxanthine-Guanine Phosphoribosyltransferase Locus.- Towards Mapping Genes to Chromosomes Using Two Dimensional Gel Electrophoresis of Proteins and Somatic Cell ...
C. Thomas Caskey, D. Christopher Robbins
openaire +2 more sources
Somatic evolution of cancer cells
Seminars in Cancer Biology, 2005Cancers develop through a process called genomic instability, which generates diversity, from which clonal evolution may occur. In colorectal cancers, this process has been extensively studied, and there are three identifiable processes involved in generating diversity at the genetic or epigenetic level.
Ajay Goel, C. Richard Boland
openaire +3 more sources
Malignancy of Somatic Cell Hybrids
Nature, 1969HARRIS et al.1 have observed the suppression of the malignancy of three types of malignant cell as a result of their fusion with cells of line A9, which they considered non-malignant. Here we supplement their data with information neglected by or unavailable to them.
B, Ephrussi +4 more
openaire +3 more sources
MicroRNAs in somatic cell reprogramming
Current Opinion in Cell Biology, 2013The generation of induced pluripotent stem (iPS) cells by exogenous transcription factors involves a comprehensive rearrangement of cellular functions, including the microRNA profile. The resulting cell lines are similar to embryonic stem (ES) cells and have therefore raised much interest for in vitro studies and the perspective of clinical application.
Christina Benda +7 more
openaire +3 more sources
Embryonic and somatic cell cloning
Reproduction, Fertility and Development, 1998Revolutionary opportunities in biology, medicine and agriculture arise from the observation that offspring are obtained after nuclear transfer if somatic donor cells are induced to become quiescent. Exploitation of many of these opportunities will depend upon optimizing procedures for nuclear transfer.
Ian Wilmut +2 more
openaire +3 more sources
1984
At the onset it should be noticed that the contents of this chapter are confined to the fusion of protoplasts; normal somatic plant cells with thick cell walls cannot fuse with each other and only naked protoplasts can do so. Nowadays fusion of protoplasts has attracted attention as the first step towards somatic hybridization, but the phenomenon is ...
openaire +2 more sources
At the onset it should be noticed that the contents of this chapter are confined to the fusion of protoplasts; normal somatic plant cells with thick cell walls cannot fuse with each other and only naked protoplasts can do so. Nowadays fusion of protoplasts has attracted attention as the first step towards somatic hybridization, but the phenomenon is ...
openaire +2 more sources