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Reprogramming of Somatic Cells
2012Reprogramming of adult somatic cells into pluripotent stem cells may provide an attractive source of stem cells for regenerative medicine. It has emerged as an invaluable method for generating patient-specific stem cells of any cell lineage without the use of embryonic stem cells.
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Reprogramming of somatic cells
2017Limited access to human neurons has posed a significant barrier to progress in biological and preclinical studies of the human nervous system. The advent of cell reprogramming technologies has widely disclosed unprecedented opportunities to generate renewable sources of human neural cells for disease modeling, drug discovery, and cell therapeutics ...
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1982
Pathway Mutants in Mammalian Cells and their Contribution to the Analysis of Drug Resistance.- Isolation and Analysis of Chinese Hamster Cells Carrying Forward and Reverse Mutations in the Hypoxanthine-Guanine Phosphoribosyltransferase Locus.- Towards Mapping Genes to Chromosomes Using Two Dimensional Gel Electrophoresis of Proteins and Somatic Cell ...
C. Thomas Caskey, D. Christopher Robbins
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Pathway Mutants in Mammalian Cells and their Contribution to the Analysis of Drug Resistance.- Isolation and Analysis of Chinese Hamster Cells Carrying Forward and Reverse Mutations in the Hypoxanthine-Guanine Phosphoribosyltransferase Locus.- Towards Mapping Genes to Chromosomes Using Two Dimensional Gel Electrophoresis of Proteins and Somatic Cell ...
C. Thomas Caskey, D. Christopher Robbins
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Somatic evolution of cancer cells
Seminars in Cancer Biology, 2005Cancers develop through a process called genomic instability, which generates diversity, from which clonal evolution may occur. In colorectal cancers, this process has been extensively studied, and there are three identifiable processes involved in generating diversity at the genetic or epigenetic level.
Ajay Goel, C. Richard Boland
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Malignancy of Somatic Cell Hybrids
Nature, 1969HARRIS et al.1 have observed the suppression of the malignancy of three types of malignant cell as a result of their fusion with cells of line A9, which they considered non-malignant. Here we supplement their data with information neglected by or unavailable to them.
B, Ephrussi +4 more
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MicroRNAs in somatic cell reprogramming
Current Opinion in Cell Biology, 2013The generation of induced pluripotent stem (iPS) cells by exogenous transcription factors involves a comprehensive rearrangement of cellular functions, including the microRNA profile. The resulting cell lines are similar to embryonic stem (ES) cells and have therefore raised much interest for in vitro studies and the perspective of clinical application.
Christina Benda +7 more
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Embryonic and somatic cell cloning
Reproduction, Fertility and Development, 1998Revolutionary opportunities in biology, medicine and agriculture arise from the observation that offspring are obtained after nuclear transfer if somatic donor cells are induced to become quiescent. Exploitation of many of these opportunities will depend upon optimizing procedures for nuclear transfer.
Ian Wilmut +2 more
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1992
Somatic hybridization is a technique which allows the manipulation of cellular genomes by protoplast fusion. Its major contribution to plant breeding is in overcoming common crossing barriers among plant species and in organelle genetics and breeding. Several reviews on different aspects of somatic hybridization were published recently: Pelletier and ...
K. C. Sink, R. K. Jain, J. B. Chowdhury
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Somatic hybridization is a technique which allows the manipulation of cellular genomes by protoplast fusion. Its major contribution to plant breeding is in overcoming common crossing barriers among plant species and in organelle genetics and breeding. Several reviews on different aspects of somatic hybridization were published recently: Pelletier and ...
K. C. Sink, R. K. Jain, J. B. Chowdhury
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1984
At the onset it should be noticed that the contents of this chapter are confined to the fusion of protoplasts; normal somatic plant cells with thick cell walls cannot fuse with each other and only naked protoplasts can do so. Nowadays fusion of protoplasts has attracted attention as the first step towards somatic hybridization, but the phenomenon is ...
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At the onset it should be noticed that the contents of this chapter are confined to the fusion of protoplasts; normal somatic plant cells with thick cell walls cannot fuse with each other and only naked protoplasts can do so. Nowadays fusion of protoplasts has attracted attention as the first step towards somatic hybridization, but the phenomenon is ...
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2014
A number of somatic stem cells have been used in inner ear research. In this chapter, two stem cells, mesenchymal and hematopoietic stem cells, are the focus, because these stem cells have already utilized in clinical settings. Of mesenchymal stem cells, the potential of bone marrow- and adipose tissue-derived stem cells for the treatment of the inner ...
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A number of somatic stem cells have been used in inner ear research. In this chapter, two stem cells, mesenchymal and hematopoietic stem cells, are the focus, because these stem cells have already utilized in clinical settings. Of mesenchymal stem cells, the potential of bone marrow- and adipose tissue-derived stem cells for the treatment of the inner ...
openaire +2 more sources