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MicroRNAs in somatic cell reprogramming
Current Opinion in Cell Biology, 2013The generation of induced pluripotent stem (iPS) cells by exogenous transcription factors involves a comprehensive rearrangement of cellular functions, including the microRNA profile. The resulting cell lines are similar to embryonic stem (ES) cells and have therefore raised much interest for in vitro studies and the perspective of clinical application.
Christina Benda +7 more
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Malignancy of Somatic Cell Hybrids
Nature, 1969HARRIS et al.1 have observed the suppression of the malignancy of three types of malignant cell as a result of their fusion with cells of line A9, which they considered non-malignant. Here we supplement their data with information neglected by or unavailable to them.
B, Ephrussi +4 more
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Embryonic and somatic cell cloning
Reproduction, Fertility and Development, 1998Revolutionary opportunities in biology, medicine and agriculture arise from the observation that offspring are obtained after nuclear transfer if somatic donor cells are induced to become quiescent. Exploitation of many of these opportunities will depend upon optimizing procedures for nuclear transfer.
Ian Wilmut +2 more
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Reprogramming of Somatic Cells to Pluripotency
2010Reprogramming of somatic cells into pluripotent stem cells has been achieved by introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006. These induced pluripotent stem (iPS) cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with ...
Shinya Yamanaka, Masato Nakagawa
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1984
At the onset it should be noticed that the contents of this chapter are confined to the fusion of protoplasts; normal somatic plant cells with thick cell walls cannot fuse with each other and only naked protoplasts can do so. Nowadays fusion of protoplasts has attracted attention as the first step towards somatic hybridization, but the phenomenon is ...
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At the onset it should be noticed that the contents of this chapter are confined to the fusion of protoplasts; normal somatic plant cells with thick cell walls cannot fuse with each other and only naked protoplasts can do so. Nowadays fusion of protoplasts has attracted attention as the first step towards somatic hybridization, but the phenomenon is ...
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2014
A number of somatic stem cells have been used in inner ear research. In this chapter, two stem cells, mesenchymal and hematopoietic stem cells, are the focus, because these stem cells have already utilized in clinical settings. Of mesenchymal stem cells, the potential of bone marrow- and adipose tissue-derived stem cells for the treatment of the inner ...
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A number of somatic stem cells have been used in inner ear research. In this chapter, two stem cells, mesenchymal and hematopoietic stem cells, are the focus, because these stem cells have already utilized in clinical settings. Of mesenchymal stem cells, the potential of bone marrow- and adipose tissue-derived stem cells for the treatment of the inner ...
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1973
Publisher Summary This chapter describes the preparation of primary cultures of somatic plant cells. Primary cultures of somatic plant cells have been established from virtually every organ or tissue and from diverse plants, from the moss to the monocotyledonous angiosperm.
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Publisher Summary This chapter describes the preparation of primary cultures of somatic plant cells. Primary cultures of somatic plant cells have been established from virtually every organ or tissue and from diverse plants, from the moss to the monocotyledonous angiosperm.
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1986
By somatic cell cytogenetics is meant the study of differentiated cells outside the germline. Since such cells usually do not divide, it is not surprising that much less is known about them than about germline or meristematic cells.
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By somatic cell cytogenetics is meant the study of differentiated cells outside the germline. Since such cells usually do not divide, it is not surprising that much less is known about them than about germline or meristematic cells.
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A tribute to somatic cell reprogrammers
MHR: Basic science of reproductive medicine, 2012For many biologists, the ‘holy grail’ has been to derive pluripotent cells that have the potential to differentiate into all cell types of the body. They represent enormous scientific value as they can be used to study differentiation, the onset of disease and, in the long term, offer a significant therapeutic potential (Colman and Dreesen, 2009). Long
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Construction of Somatic Cell Hybrids
Current Protocols in Human Genetics, 1996AbstractSomatic cell hybridization is the method of choice to separate a chromosome of interest from the full chromosome complement and obtain a permanent source of the chromosome. This unit begins with the choice of fusion techniques and selectable markers for hybrids containing a chromosome of interest.
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