Results 41 to 50 of about 363,529 (321)

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Single-base resolution methylomes of somatic embryogenesis in Theobroma cacao L. reveal epigenome modifications associated with somatic embryo abnormalities

Scientific Reports, 2022
Propagation by somatic embryogenesis in Theobroma cacao has some issues to be solved, as many morphologically abnormal somatic embryos that do not germinate into plants are frequently observed, thus hampering plant production on a commercial scale.
Claudia Garcia, Alex-Alan Furtado de Almeida, Marcio Costa, Dahyana Britto, Fabio Correa, Pedro Mangabeira, Lidiane Silva, Jose Silva, Stefan Royaert, Jean-Philippe Marelli   +9 more
doaj   +1 more source

The human brain through the lens of somatic mosaicism

Frontiers in Neuroscience, 2023
Every cell in the human brain possesses a unique genome that is the product of the accumulation of somatic mutations starting from the first postzygotic cell division and continuing throughout life. Somatic mosaicism in the human brain has been the focus
Sara Bizzotto
doaj   +1 more source

Conductance-based dendrites perform Bayes-optimal cue integration [PDF]

arXiv, 2021
A fundamental function of cortical circuits is the integration of information from different sources to form a reliable basis for behavior. While animals behave as if they optimally integrate information according to Bayesian probability theory, the implementation of the required computations in the biological substrate remains unclear.
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

A quantitative system for discriminating induced pluripotent stem cells, embryonic stem cells and somatic cells [PDF]

, 2012
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines. However, an efficient system to discriminate the cell lines is lacking.
arxiv   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Superior migration ability of umbilical cord-derived mesenchymal stromal cells (MSCs) toward activated lymphocytes in comparison with those of bone marrow and adipose-derived MSCs

Frontiers in Cell and Developmental Biology
Introduction: Mesenchymal stromal cells (MSCs) are activated upon inflammation and/or tissue damage and migrate to suppress inflammation and repair tissues.
Akiko Hori, Akiko Hori, Akiko Hori, Atsuko Takahashi, Atsuko Takahashi, Atsuko Takahashi, Yuta Miharu, Yuta Miharu, Yuta Miharu, Satoru Yamaguchi, Masatoshi Sugita, Takeo Mukai, Fumitaka Nagamura, Tokiko Nagamura-Inoue, Tokiko Nagamura-Inoue, Tokiko Nagamura-Inoue   +15 more
doaj   +1 more source

Heritabilities and genetic correlations of lactational and daily somatic cell score with conformation traits in Polish Holstein cattle

Czech Journal of Animal Science, 2011
The objective of this study was to estimate heritabilities and genetic correlations of lactational and daily somatic cell scores with descriptive and linear type traits in Polish Holstein-Friesian cows.
E. Ptak, W. Jagusiak, A. Żarnecki, A. Otwinowska-Mindur   +3 more
doaj   +1 more source

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations [PDF]

, 2017
How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of cancer? To answer the question we consider a general model of hierarchically organized self-renewing tissues and show that the lifetime ...
arxiv   +1 more source