Results 41 to 50 of about 637,874 (359)

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
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Extinction of gene expression in somatic cell hybrids. a reflection of important regulatory mechanisms? [PDF]

, 1993
Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
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Relationship of daily total somatic cell output with somatic cell concentration and clinical mastitis

JDS Communications, 2021
Somatic cell count (SCC) measures the concentration of somatic cells in milk and is used as a mastitis diagnostic tool. It is plausible that variation in milk yield could alter the relationship between SCC and mastitis status.
H.P. Lehew, C.D. Dechow
doaj   +1 more source

A cancer cell-line titration series for evaluating somatic classification. [PDF]

, 2015
BackgroundAccurate detection of somatic single nucleotide variants and small insertions and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging task.
Beck, Timothy, Brown, Andrew MK, Denroche, Robert E, McPherson, John D, Mullen, Laura, Stein, Lincoln, Timms, Lee, Yung, Christina K   +7 more
core   +2 more sources

Trade-off between somatic and germline repair in a vertebrate supports the "expensive germ line" hypothesis [PDF]

, 2020
The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301–304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B Biol. Sci. 205, 531–546 (1979); T.
Bublys, Kasparas, Chen, Hwei-Yen, Immler, Simone, Jolly, Cecile, Marcu, Daniel   +4 more
core   +1 more source

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]

, 2012
Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Chiranjeevi Sandi, David T. Kirkpatrick, Irene De Biase, Mark A. Pook, Rebecka L. Bourn, Ricardo Mouro Pinto, Sahar Al-Mahdawi, Sanjay I. Bidichandani   +7 more
core   +2 more sources

Differential leukocyte count method for bovine low somatic cell count milk [PDF]

, 2003
Whereas many differential leukocyte count methods for high somatic cell count (SCC) milk from mastitic cows are available, only a few have been developed for low SCC milk.
Burvenich, Christian, Dosogne, Hilde, MASSART-LEEN, AM, MEHRZAD, J, Vangroenweghe, Frédéric   +4 more
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Contagem celular somática: relação com a composição centesimal do leite e período do ano no Estado de Goiás Somatic cell count: relationship to milk composition and period of the year in Goiás State, Brazil

Ciência Rural, 2005
Apesar de estar entre os maiores produtores de leite do país, o Estado de Goiás não tem estudos abrangentes e atualizados relativos à qualidade do leite.
Válter Ferreira Félix Bueno, Albenones José de Mesquita, Edmar Soares Nicolau, Antônio Nonato de Oliveira, Jaison Pereira de Oliveira, Rodrigo Balduíno Soares Neves, José Ricardo Garcia Mansur, Liandra Werner Thomaz   +7 more
doaj   +1 more source

Dissecting Human Gonadal Cell Lineage Specification and Sex Determination Using A Single-cell RNA-seq Approach

Genomics, Proteomics & Bioinformatics, 2022
Gonadal somatic cells are the main players in gonad development and are important for sex determination and germ cell development. Here, using a time-series single-cell RNA sequencing (scRNA-seq) strategy, we analyzed fetal germ cells (FGCs) and gonadal ...
Rui Wang, Xixi Liu, Li Li, Ming Yang, Jun Yong, Fan Zhai, Lu Wen, Liying Yan, Jie Qiao, Fuchou Tang   +9 more
doaj   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
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