Results 91 to 100 of about 147,116 (329)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Response to somatic cell count-based selection for mastitis resistance in a divergent selection experiment in sheep [PDF]

, 2009
A divergent selection experiment in sheep was implemented to study the consequences of log-transformed somatic cell score (SCS)-based selection on resistance to natural intramammary infections.
Aurel, Marie-Rose, Bergonier, Dominique, Dion, Stéphane, Foucras, Gilles, Hygonenq, Marie-Claude, Robert-Granié, Christèle, Rupp, Rachel   +6 more
core   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Effects of somatic cell count in subclinical mastitis on raw milk quality in dairy farms of Khuzestan province [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2016
Mastitis is an infectious disease that is spread in livestock and can cause cattle mortality. Generally a cow with mastitis has a 15 per cent decrease in milk production.
mohammad Hossieni nejad, zohreh Mashak
doaj  

RESEARCHES REGARDING COW-MILK’S QUALITY OBTAINED IN THREE FARMS FORM ALBA COUNTY

Scientific Papers Animal Science and Biotechnologies, 2023
In the selection process, along with the milk quantity obtained from an animal, an important part is the milk quality, which has a big influence in the recalculated milk quantity and also in its nutritive, energetic and biological value which the milk ...
E. JURCO, G. MUREŞAN
doaj  

Pilot study into milk haptoglobin as an indicator of udder health in heifers after calving [PDF]

, 2018
Mastitis, inflammation of the mammary gland, is often caused by intramammary infection with bacterial organisms. It impacts on dairy cattle welfare, production, udder health and longevity in the herd.
Campbell, M., Eckersall, P.D., Geraghty, T.E., Gibbons, J., Simões, P.B.A., Viora, L., Zadoks, R.N.   +6 more
core   +1 more source

Combined burden and functional impact tests for cancer driver discovery using DriverPower [PDF]

, 2020
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across ...
, , Abascal, Federico, Amin, Samirkumar B., Bader, Gary D., Bandopadhayay, Pratiti, Barenboim, Jonathan, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A., Brunak, Søren, Campbell, Peter J., Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, Deu-Pons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J. Lynn, Fonseca, Nuno A., Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W., Gerstein, Mark, Getz, Gad, Guo, Qianyun, Gut, Ivo G., Haan, David, Hamilton, Mark P., Haradhvala, Nicholas J., Harmanci, Arif O., Helmy, Mohamed, Herrmann, Carl, Hess, Julian M., Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Hornshøj, Henrik, Isaev, Keren, Izarzugaza, Jose M.G., Johnson, Rory, Johnson, Todd A., Juul, Malene, Juul, Randi Istrup, Kahles, Andre, Kahraman, Abdullah, Kellis, Manolis, Khurana, Ekta, Shuai, Shimin, Stein, Lincoln D., Townend, David   +53 more
core   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

Veterinární Medicína, 2006
The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme.
K. Wojdak-Maksymiec, M. Kmiec, J. Ziemak
doaj   +1 more source

Influence of Blood and Milk Selenium Concentration on Somatic Cell Count in Early and Mid Lactation [PDF]

, 2015
The aim of this study was to determine the effect of selenium concentration in blood and milk in early lactation on somatic cell count. The average selenium concentration in the blood serum was 0.62 ± 0.11 μmol/l and in the milk serum 0.61 ± 0.07 μmol/l.
Belic, B, Cincovic, M.R., Davidov, I, Djokovic, R, Erdeljan, M, Radinovic, M   +5 more
core