Results 111 to 120 of about 159,844 (352)

Association of Breed of Sheep or Goats with Somatic Cell Counts and Total Bacterial Counts of Bulk-Tank Milk [PDF]

open access: gold, 2021
Daphne T. Lianou   +6 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Herd Composite Somatic Cell Counts: Average Linear Score and Weighted Average Somatic Cell Count Score and Milk Production

open access: yesJournal of Dairy Science, 1988
The relationship between herd production weighted average somatic cell count (average of somatic cell count weighted by individual cow milk production) and average linear score (average of individual cow linear score somatic cell counts) was investigated using three models.
John Fetrow   +3 more
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model. [PDF]

open access: yes, 2014
peer-reviewedBovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per annum.
Baker, Mike   +10 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Farmers’ reaction upon receiving economic information in controlling somatic cell count [PDF]

open access: yes
Adoption and implementation of efficient somatic cell count (SCC) control practices is an action of behavioral change, which is notoriously difficult to achieve and sustain, even when substantial production and economic gains are to be expected.
Asseldonk, M.A.P.M., van   +3 more
core  

Genetic correlations among somatic cell scores, productive life, and type traits from the United States and udder health measures from Denmark and Sweden [PDF]

open access: yes, 1998
Sire genetic evaluations for protein yield, somatic cell score (SCS), productive life, and udder type traits from the US were correlated with sire evaluations for udder health from Denmark and Sweden and then the correlations were adjusted for accuracies
Banos, G   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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