Results 101 to 110 of about 63,552 (337)

Erratum: Production of gene-targeted sheep by nuclear transfer from cultured somatic cells [PDF]

, 2000
K. J. McCreath, J. Howcroft, Keith Campbell, Alex Colman, A. E. Schnieke, A. J. Kind   +5 more
openalex   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Cell Reports, 2018
Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming.
Kei Miyamoto, Khoi T. Nguyen, George E. Allen, Jerome Jullien, Dinesh Kumar, Tomoki Otani, Charles R. Bradshaw, Frederick J. Livesey, Manolis Kellis, John B. Gurdon   +9 more
doaj  

High histone crotonylation modification in bovine fibroblasts promotes cell proliferation and the developmental efficiency of preimplantation nuclear transfer embryos

Scientific Reports
Lysine crotonylation (Kcr) is a recently discovered histone acylation modification that is closely associated with gene expression, cell proliferation, and the maintenance of stem cell pluripotency and indicates the transcriptional activity of genes and ...
Xiaoyu Zhao, Mengxin Du, Shanshan Wu, Zhiwen Du, Shuqin Liu, Lei Yang, Haoran Ma, Liguo Zhang, Lishuang Song, Chunling Bai, Guanghua Su, Guangpeng Li   +11 more
doaj   +1 more source

A long non-coding RNA essential for early embryonic development improves somatic cell nuclear transfer somatic cell nuclear transfer efficiency in goats. [PDF]

Reproduction, 2023
Jin M, Zhao L, Yang H, Zhao J, Ma H, Chen Y, Zhang J, Luo Y, Zhang Y, Liu J.   +9 more
europepmc   +1 more source

Generation of biallelic knock-out sheep via gene-editing and somatic cell nuclear transfer

Scientific Reports, 2016
Transgenic sheep can be used to achieve genetic improvements in breeds and as an important large-animal model for biomedical research. In this study, we generated a TALEN plasmid specific for ovine MSTN and transfected it into fetal fibroblast cells of ...
Honghui Li, Gui Wang, Zhiqiang Hao, Guozhong Zhang, Yubo Qing, Shuanghu Liu, Lili Qing, Weirong Pan, Lei Chen, Guichun Liu, Ruoping Zhao, B. Jia, Luyao Zeng, Jianxiong Guo, Lixiang Zhao, Heng Zhao, Chaoxiang Lv, Kaixiang Xu, W. Cheng, Hushan Li, Hong-Ye Zhao, Wen Wang, Hongjiang Wei   +22 more
semanticscholar   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Cloned Transgenic Offspring Resulting from Somatic Cell Nuclear Transfer in the Goat: Oocytes Derived from Both Follicle-Stimulating Hormone-Stimulated and Nonstimulated Abattoir-Derived Ovaries1 [PDF]

, 2001
B.C. Reggio, Aidita N. James, Heather L. Green, W. Gavin, E. Behboodi, Yann Echelard, R.A. Godke   +6 more
openalex   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Abnormal gene expression in regular and aggregated somatic cell nuclear transfer placentas

BMC Biotechnology, 2017
Background Placental defects in somatic cell nuclear transfer (SCNT) are a major cause of complications during pregnancy. One of the most critical factors for the success of SCNT is the successful epigenetic reprogramming of donor cells. Recently, it was
Bo-Woong Sim, Chae-Won Park, Myung-Hwa Kang, Kwan-Sik Min   +3 more
doaj   +1 more source