Results 101 to 110 of about 267,878 (327)

High histone crotonylation modification in bovine fibroblasts promotes cell proliferation and the developmental efficiency of preimplantation nuclear transfer embryos

Scientific Reports
Lysine crotonylation (Kcr) is a recently discovered histone acylation modification that is closely associated with gene expression, cell proliferation, and the maintenance of stem cell pluripotency and indicates the transcriptional activity of genes and ...
Xiaoyu Zhao, Mengxin Du, Shanshan Wu, Zhiwen Du, Shuqin Liu, Lei Yang, Haoran Ma, Liguo Zhang, Lishuang Song, Chunling Bai, Guanghua Su, Guangpeng Li   +11 more
doaj   +1 more source

Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash, Tiffany W. Martin, Amber R. Prebble, Del Leary   +3 more
wiley   +1 more source

Construction of transgenic swine with induced expression of Cre recombinase

Animal, 2010
Miniature pigs have been recognized as valuable experimental animals in medical research. However, porcine models related to gene knockout of human diseases are not widely available. The objective of this study was to establish Mx1-Cre pigs using somatic
L. Chen, L. Li, D. Pang, Z. Li, T. Wang, M. Zhang, N. Song, S. Yan, L.X. Lai, H. Ouyang   +9 more
doaj  

Various nuclear reprogramming systems using egg and oocyte materials

The Journal of Reproduction and Development, 2019
Maternal factors stored in eggs and oocytes are necessary for reprogramming sperm for embryonic development. This reprogramming activity of maternal factors also works towards somatic cells, including terminally differentiated cells.
Kei MIYAMOTO
doaj   +1 more source

A long non-coding RNA essential for early embryonic development improves somatic cell nuclear transfer somatic cell nuclear transfer efficiency in goats. [PDF]

Reproduction, 2023
Jin M, Zhao L, Yang H, Zhao J, Ma H, Chen Y, Zhang J, Luo Y, Zhang Y, Liu J.   +9 more
europepmc   +1 more source

Human somatic cell nuclear transfer (cloning) [PDF]

, 2000

openalex   +1 more source

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Cell Reports, 2018
Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming.
Kei Miyamoto, Khoi T. Nguyen, George E. Allen, Jerome Jullien, Dinesh Kumar, Tomoki Otani, Charles R. Bradshaw, Frederick J. Livesey, Manolis Kellis, John B. Gurdon   +9 more
doaj  

Erratum: Production of gene-targeted sheep by nuclear transfer from cultured somatic cells [PDF]

, 2000
K. J. McCreath, J. Howcroft, Keith Campbell, Alex Colman, A. E. Schnieke, A. J. Kind   +5 more
openalex   +1 more source

Flatsomatic: A Method for Compression of Somatic Mutation Profiles in Cancer [PDF]

arXiv, 2019
In this study, we present Flatsomatic - a Variational Auto Encoder (VAE) optimized to compress somatic mutations that allow for unbiased data compression whilst maintaining the signal. We compared two different neural network architectures for the VAE: Multilayer Perceptron (MLP) and bidirectional LSTM.
arxiv  

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source