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Cattle Cloning by Somatic Cell Nuclear Transfer
2023Cloning by somatic cell Nuclear Transfer (SCNT) is a powerful technology capable of reprograming terminally differentiated cells to totipotency for generating whole animals or pluripotent stem cells for use in cell therapy, drug screening, and other biotechnological applications. However, the broad usage of SCNT remains limited due to its high cost and
Juliano Rodrigues, Sangalli +4 more
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Bovid Interspecies Somatic Cell Nuclear Transfer with Ooplasm Transfer
2023Interspecies somatic cell nuclear transfer (iSCNT) contributes to the preservation of endangered species, albeit nuclear-mitochondrial incompatibilities constrain its application. iSCNT, coupled with ooplasm transfer (iSCNT-OT), has the potential to overcome the challenges associated with species- and genus-specific differences in nuclear-mitochondrial
L Antonio, González-Grajales +1 more
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Cellular Reprogramming, 2018
Biobanks of cryopreserved gametes and embryos of domestic animals have been utilized to spread desired genotypes and to conserve the animal germplasm of endangered breeds. In principle, somatic cells can be used for the same purposes, and for reviving of
N. Selokar +8 more
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Biobanks of cryopreserved gametes and embryos of domestic animals have been utilized to spread desired genotypes and to conserve the animal germplasm of endangered breeds. In principle, somatic cells can be used for the same purposes, and for reviving of
N. Selokar +8 more
semanticscholar +1 more source
Pig Cloning Using Somatic Cell Nuclear Transfer
2020Porcine cloning technology can be used to produce progenies genetically identical to the donor cells from high-quality breeding pigs. In addition, genetically modified pigs have been produced by somatic cell nuclear transfer using genetically modified porcine fetal fibroblasts.
Hongsheng, Ouyang +2 more
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Somatic Cell Nuclear Transfer in the Mouse
2008Somatic cell nuclear transfer (SCNT) has become a unique and powerful tool for epigenetic reprogramming research and gene manipulation in animals since "Dolly," the first animal cloned from an adult cell was reported in 1997. Although the success rates of somatic cloning have been inefficient and the mechanism of reprogramming is still largely unknown,
Satoshi, Kishigami, Teruhiko, Wakayama
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Progress in Human Somatic-Cell Nuclear Transfer
New England Journal of Medicine, 2005The efficiency of deriving blastocysts through the nuclear transfer of embryonic stem cells has been improved by a factor of more than 14.
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Animal Cloning by Somatic Cell Nuclear Transfer
2009Animal cloning is becoming increasingly useful for its applications in biological inquiry and for its potential use in pharmaceutical, medical, and agricultural fields. Due to the complexity of the numerous steps required in reconstructing oocytes by nuclear transfer, detailed protocols are required to minimize the developmental damages inflicted ...
Lawrence C, Smith, Jae-Gyu, Yoo
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Human somatic cell nuclear transfer and cloning
Fertility and Sterility, 2012This document presents arguments that conclude that it is unethical to use somatic cell nuclear transfer (SCNT) for infertility treatment due to concerns about safety; the unknown impact of SCNT on children, families, and society; and the availability of other ethically acceptable means of assisted reproduction.
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The many problems of somatic cell nuclear transfer in reproductive cloning of mammals.
Theriogenology, 2022Katarzyna Malin +2 more
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Cloning of Monkeys by Somatic Cell Nuclear Transfer
2020Somatic cell nuclear transfer (SCNT) is a promising method to establish genetically modified monkeys with identical genetic background as models in biomedical research. We have recently cloned monkeys by optimization of the SCNT protocols and inclusion of the epigenetic modulator.
Shiyu, Sun +3 more
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