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Somatic Cell Nuclear Transfer in Horses
Reproduction in Domestic Animals, 2008ContentsThe cloning of equids was achieved in 2003, several years after the birth of Dolly the sheep and also after the cloning of numerous other laboratory and farm animal species. The delay was because of the limited development in the horse of more classical‐assisted reproductive techniques required for successful cloning, such as oocyte maturation ...
Silvia Colleoni +4 more
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Somatic cell nuclear transfer and centrosome inheritance
Hereditas (Beijing), 2008The developmental competence of embryos cloned from somatic cells depends on the cellular event and molecular process, such as separation of chromosomes and reorganization of spindle after nuclear transfer. Centrosome, the main microtubule organizing centers in a cell, is crucial for reorganization of spindle and normal separation of chromosomes during
Hua-Bin Zhu +3 more
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Somatic Cell Nuclear Transfer in the Mouse
2008Somatic cell nuclear transfer (SCNT) has become a unique and powerful tool for epigenetic reprogramming research and gene manipulation in animals since "Dolly," the first animal cloned from an adult cell was reported in 1997. Although the success rates of somatic cloning have been inefficient and the mechanism of reprogramming is still largely unknown,
Satoshi Kishigami, Teruhiko Wakayama
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Bovine Somatic Cell Nuclear Transfer
2010Somatic cell nuclear transfer (SCNT) is a technique by which the nucleus of a differentiated cell is introduced into an oocyte from which its genetic material has been removed by a process called enucleation. In mammals, the reconstructed embryo is artificially induced to initiate embryonic development (activation).
Pablo J. Ross, Jose B. Cibelli
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Epigenetic Reprogramming and Somatic Cell Nuclear Transfer
2023Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During mammalian development, there are two global waves
Luna N, Vargas +2 more
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Australian Journal of Experimental Agriculture, 2004
Nuclear transfer research became front-page news when the birth of Dolly, the cloned ewe, was reported by Ian Wilmut and Keith Campbell in 1997. Since Dolly’s birth, offspring from many other species have been produced using somatic cell nuclear transfer.
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Nuclear transfer research became front-page news when the birth of Dolly, the cloned ewe, was reported by Ian Wilmut and Keith Campbell in 1997. Since Dolly’s birth, offspring from many other species have been produced using somatic cell nuclear transfer.
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2019
In biological system, the term “cloning” has different meanings. Animal cloning, the somatic cell nuclear transfer (SCNT) cloning, became a buzzword when Dolly, the first mammalian species was born from the nuclear transfer of fibroblasts taken from adult sheep.
Birbal Singh +3 more
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In biological system, the term “cloning” has different meanings. Animal cloning, the somatic cell nuclear transfer (SCNT) cloning, became a buzzword when Dolly, the first mammalian species was born from the nuclear transfer of fibroblasts taken from adult sheep.
Birbal Singh +3 more
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Cloning of Monkeys by Somatic Cell Nuclear Transfer
2020Somatic cell nuclear transfer (SCNT) is a promising method to establish genetically modified monkeys with identical genetic background as models in biomedical research. We have recently cloned monkeys by optimization of the SCNT protocols and inclusion of the epigenetic modulator.
Zhen Liu +3 more
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Cattle Cloning by Somatic Cell Nuclear Transfer
2023Cloning by somatic cell Nuclear Transfer (SCNT) is a powerful technology capable of reprograming terminally differentiated cells to totipotency for generating whole animals or pluripotent stem cells for use in cell therapy, drug screening, and other biotechnological applications. However, the broad usage of SCNT remains limited due to its high cost and
Juliano Rodrigues, Sangalli +4 more
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Human somatic cell nuclear transfer and cloning
Fertility and Sterility, 2012This document presents arguments that conclude that it is unethical to use somatic cell nuclear transfer (SCNT) for infertility treatment due to concerns about safety; the unknown impact of SCNT on children, families, and society; and the availability of other ethically acceptable means of assisted reproduction.
Judith Daar +18 more
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