Results 211 to 220 of about 388,319 (399)

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

open access: yesBiological Reviews, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Canonical and Non‐Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer

open access: yesCancer Science, EarlyView.
Histone H3K4‐modifying enzymes regulate gene expression and cellular processes critical to cancer development. Beyond their canonical roles, these enzymes also exhibit non‐catalytic and non‐histone functions, offering new opportunities for therapeutic intervention. ABSTRACT Histone H3K4 modifications are altered in the regulation of gene expression and
Takayuki Hoshii
wiley   +1 more source

The Impact of Polyploid Giant Cancer Cells: The Root of Stress Resilience

open access: yesCancer Science, EarlyView.
Among the diverse characteristics of polyploid giant cancer cells (PGCCs) observed in various contexts, stress resilience is one of their key features, enabling survival and adaptation under harsh conditions. This review discusses the unique stress tolerance mechanisms of PGCCs and their implications for cancer progression, therapy resistance, and ...
Yuta Ogawa   +2 more
wiley   +1 more source

PIK3C2A‐Related Clinical Phenotype and Cellular Charaterization Linked to Functional SHH Primary Cilia Defect

open access: yesClinical Genetics, EarlyView.
Trio exome sequencing allowed the identification of two novel compound heterozygous variants in PIK3C2A, defining the fifth family presenting a PIK3C2A‐related syndrome characterized by pulverulent cataracts and deafness. Functional testing revealed impaired PI metabolism and primary dysfunction phenotype.
Adella Karam   +9 more
wiley   +1 more source

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