Results 141 to 150 of about 49,767 (265)

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Spatiotemporal transcriptome and metabolome landscapes of cotton somatic embryos. [PDF]

Nat Commun
Ge X, Yu X, Liu Z, Yuan J, Qin A, Wang Y, Chen Y, Qin W, Liu Y, Liu X, Zhou Y, Wang P, Yang J, Liu H, Zhao Z, Hu M, Zhang Y, Sun S, Herrera-Estrella L, Tran LP, Sun X, Li F.   +21 more
europepmc   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Author Correction: Spatiotemporal transcriptome and metabolome landscapes of cotton somatic embryos. [PDF]

Nat Commun
Ge X, Yu X, Liu Z, Yuan J, Qin A, Wang Y, Chen Y, Qin W, Liu Y, Liu X, Zhou Y, Wang P, Yang J, Liu H, Zhao Z, Hu M, Zhang Y, Sun S, Herrera-Estrella L, Tran LP, Sun X, Li F.   +21 more
europepmc   +1 more source

Pretreatment and posttreatment in the biolistic transformation of tea plant (Camellia sinensis) somatic embryos. [PDF]

Plant Biotechnol (Tokyo), 2020
Furukawa K, Koizumi M, Hayashi W, Mochizuki H, Yamaki K.   +4 more
europepmc   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Leveraging Walnut Somatic Embryos as a Biomanufacturing Platform for Recombinant Proteins and Metabolites. [PDF]

BioTech (Basel)
Zaini PA, Haddad KR, Feinberg NG, Ophir Y, Nandi S, McDonald KA, Dandekar AM.   +6 more
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Transcriptomic Analysis of Osmotic Stress-Tolerant Somatic Embryos of <i>Coffea arabica</i> L. Mediated by the Coffee Antisense <i>Trehalase</i> Gene: A Marker-Free Approach. [PDF]

Int J Mol Sci
Valencia-Lozano E, Barraza A, Ibarra J, Délano-Frier JP, Martínez-Gallardo NA, Gámez-Escobedo IA, Cabrera-Ponce JL.   +6 more
europepmc   +1 more source

Changes in abscisic acid metabolism in relation to the maturation of grapevine (Vitis vinifera L., cv. Mencía) somatic embryos. [PDF]

BMC Plant Biol, 2020
Acanda Y, Martínez Ó, Prado MJ, González MV, Rey M.   +4 more
europepmc   +1 more source