Results 81 to 90 of about 1,181,626 (323)

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

open access: yesBlood, 2018
Abstract Background: The pathogenesis of Myelodysplastic Syndromes (MDS) is linked to constitutive innate immune stimulation that converges upon the NLRP3 inflammasome to induce pyroptosis, a caspase-1 dependent cell death. We have shown that inflammasome assembly is initiated by both cell-extrinsic stimuli such as S100A9 elaborated by ...
Amy F McLemore   +12 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Applied Research Automatic Self-Talk Questionnaire for Sports (ASTQS): Development and Preliminary Validation of a Measure Identifying the Structure of Athletes’ Self-Talk [PDF]

open access: yes, 2009
The aim of the present investigation was to develop an instrument assessing the con­tent and the structure of athletes’ self-talk. The study was conducted in three stages.
Chroni, Stiliani   +4 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

open access: yeseLife, 2019
Neurons contain polarised microtubule arrays essential for neuronal function. How microtubule nucleation and polarity are regulated within neurons remains unclear.
A. Mukherjee   +4 more
semanticscholar   +1 more source

Professorial Reflections: informal discussions and reflections [PDF]

open access: yes, 2014
We open our issue with ‘Professorial Reflections’ – an informal, but nonetheless productive discussion about researching spirituality in dance and performance studies. We aim to offer this type of discussion, between different leading professors in dance
Meyer-Dinkgräfe, Daniel   +1 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

A Santa with a Butt Plug:Paul McCarthy and the Obliterating Violence of Positivity [PDF]

open access: yes, 2020
Kitsch is often seen as the denial of shit. Kitsch excludes from view everything that is unacceptable in human existence. In Paul McCarthy’s oeuvre, there is no such dichotomy.
Lushetich, Natasha
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Characteristics of psychoemotional adaptation of finno-ugric women (selcups) to pregnancy

open access: yesRUDN Journal of Medicine, 2010
The authors carried out a study of reproductive health of 285 Finno-ugric women. Out of it there were 100 Selcup women, 140 Udmurt and 50 Russian women.
R A Krasovitsky   +3 more
doaj  

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