Results 71 to 80 of about 109,480 (283)

Smartphone dependency, digital amnesia, and somatic symptoms among nursing students: the challenge of artificial intelligence

open access: yesBMC Nursing
Background As we advance into the digital era, the latest challenge in smartphone technology is integrating artificial intelligence applications, which have recently been incorporated into learning environments.
Lamiaa Abd El Hakeem Ali   +3 more
doaj   +1 more source

The relationship between social physique anxiety and psychosocial health in adolescents [PDF]

open access: yes, 2018
Social physique anxiety (SPA) is a subtype of social anxiety that relates to body concerns in social contexts and has been proposed as an indicator of psychosocial adjustment in adolescents. The purpose of this study is to explore the relationship of SPA
Calmeiro, Luis, Matos, M. G.
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Characteristics of psychoemotional adaptation of finno-ugric women (selcups) to pregnancy

open access: yesRUDN Journal of Medicine, 2010
The authors carried out a study of reproductive health of 285 Finno-ugric women. Out of it there were 100 Selcup women, 140 Udmurt and 50 Russian women.
R A Krasovitsky   +3 more
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Privileging exploratory hands: prehension, apprehension, comprehension [PDF]

open access: yes, 2013
Through our hands we construct our world and through our construction of our world we construct ourselves. We reach with our hands and touch with our hands, and with this reaching and touching we come to understand how things feel and are.
Stuart, S.A.J.
core  

Towards multiple interactions of inner and outer sensations in corporeal awareness [PDF]

open access: yes, 2015
Under normal circumstances, different inner- and outer-body sources are integrated to form coherent and accurate mental experiences of the state of the body, leading to the phenomenon of corporeal awareness. How these processes are affected by changes in
LUCCI, Giuliana, PAZZAGLIA, Mariella
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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