Results 51 to 60 of about 109,480 (283)

Initial OCT4 engagement with the somatic proteome during reprogramming to iPSC

, 2020
Cellular reprogramming to pluripotency can be achieved by using a defined cocktail of transcription factors, converting differentiated somatic cells into induced pluripotent stem cells (iPSCs). These cells behave like embryonic stem cells (ES) and can be used to generate all cell types in the body. OCT4, SOX2, KLF4 and cMYC (OSKM) were the first set of
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

East African HIV care: depression and HIV outcomes. [PDF]

, 2019
Importance:Depression is a common co-morbidity for people living with HIV (PLWH) and is associated with elevated plasma HIV RNA levels. While depression correlates with deficits in antiretroviral (ARV) adherence, little data exist to inform the ...
Adamu, Y, Ake, JA, Kiweewa, F, Maganga, L, Maswai, J, McCulloch, CE, Meffert, SM, Neylan, TC, Owuoth, J, Polyak, CS, Valcour, VG   +10 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Empirical verification of self-rated positive health (somatic dimension) in women with professional competence in the field of health education

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2019
Purpose: to address a question whether reports of young women concerning their positive health are concordant with indices based on recommended methods of measuring health?
D. Dobosz
doaj   +1 more source

Viewing the personality traits through a cerebellar lens. A focus on the constructs of novelty seeking, harm avoidance, and alexithymia [PDF]

, 2016
The variance in the range of personality trait expression appears to be linked to structural variance in specific brain regions. In evidencing associations between personality factors and neurobiological measures, it seems evident that the cerebellum has
Cutuli, Debora, Laricchiuta, Daniela, Petrosini, Laura, Picerni, Eleonora   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nanopolitics: A First Outline of Our Experiments in Movement

Lateral, 2012
The London-based nanopolitics group formed around a desire to think politics with and through the body, organising movement, theatre, and somatic based workshops and discussions.
The Nanopolitics Group
doaj   +1 more source