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Somatic mutations in aging and disease
GeroScienceTime always leaves its mark, and our genome is no exception. Mutations in the genome of somatic cells were first hypothesized to be the cause of aging in the 1950s, shortly after the molecular structure of DNA had been described. Somatic mutation theories of aging are based on the fact that mutations in DNA as the ultimate template for all cellular ...
Peijun Ren, Jie Zhang, Jan Vijg
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Neonatal Immunity and Somatic Mutation
International Reviews of Immunology, 2000Neonatal animals are able to mount an effective immune response, both humoral and cellular, when immunized using conditions that maximize stimulation of antigen presenting cells, T cells, and B cells. In adults, somatic mutation is a key feature of the humoral immune response because it contributes to the generation of high affinity memory B cells ...
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Somatic Mutations in “Benign” Disease
New England Journal of Medicine, 2021Osama, Dasa, Thomas A, Pearson
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Brain Somatic Mutation in Aging and Alzheimer's Disease
Annual Review of Genomics and Human Genetics, 2021, Christopher A Walsh
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Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging
Cell, 2020Jan Vijg, Xiao Dong
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A phylogenomic approach reveals a low somatic mutation rate in a long-lived plant
Proceedings of the Royal Society B: Biological Sciences, 2020Adam J Orr +2 more
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