Results 41 to 50 of about 746,068 (249)

HNSC samples somatic mutation data

, 2014
TCGA HNSC samples somatic mutation data in BED format.
Endre Sebestyén (403853)
core   +1 more source

The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

, 2021
We characterize the landscape of somatic mutations-mutations occurring after fertilization-in the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal cortex from 59 donors with autism spectrum disorder (ASD) and 15 control donors ...
Walsh, Christopher A., Brain Somatic Mosaicism Network, Rodin, Rachel E.   +2 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Development of somatic mutation signatures for risk stratification and prognosis in lung and colorectal adenocarcinomas

BMC Medical Genomics, 2019
Background Prognostic signatures are vital to precision medicine. However, development of somatic mutation prognostic signatures for cancers remains a challenge.
Mark Menor, Yong Zhu, Yu Wang, Jicai Zhang, Bin Jiang, Youping Deng   +5 more
doaj   +1 more source

KIRC samples somatic mutation data

, 2014
TCGA KIRC samples somatic mutation data in BED format.
Endre Sebestyén (403853)
core   +1 more source

Human somatic mutation assays as biomarkers of carcinogenesis. [PDF]

, 1991
This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay.
Smith, MT, M T Smith, Hooper, K, K Hooper, Compton, PJ, P J Compton   +5 more
core   +1 more source

A comparative analysis of somatic mutations occurring at "common" loci and other loci with the TCGA somatic mutation dataset.

, 2023
<p>A comparative analysis of somatic mutations occurring at "common" loci and other loci with the TCGA somatic mutation dataset.</p ...
Mengyao, WANG
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Differences between germline and somatic mutation rates in humans and mice

Nature Communications, 2017
Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species ...
Brandon Milholland, Xiao Dong, Lei Zhang, Xiaoxiao Hao, Yousin Suh, Jan Vijg   +5 more
doaj   +1 more source

Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease. [PDF]

PLoS ONE, 2012
Polycystic liver disease (PCLD) is an autosomal dominant disorder characterised by multiple fluid filled cysts in the liver. This rare disease is caused by heterozygous germline mutations in PRKCSH and SEC63.
Manoe J Janssen, Jody Salomon, René H M Te Morsche, Joost P H Drenth   +3 more
doaj   +1 more source