Results 111 to 120 of about 1,861,621 (385)

Somatic mutation rates scale with time not growth rate in long-lived tropical trees

eLife
The rates of appearance of new mutations play a central role in evolution. However, mutational processes in natural environments and their relationship with growth rates are largely unknown, particular in tropical ecosystems with high biodiversity. Here,
Akiko Satake, Ryosuke Imai, Takeshi Fujino, Sou Tomimoto, Kayoko Ohta, Mohammad Na'iem, Sapto Indrioko, Widiyatno Widiyatno, Susilo Purnomo, Almudena Molla Morales, Viktoria Nizhynska, Naoki Tani, Yoshihisa Suyama, Eriko Sasaki, Masahiro Kasahara   +14 more
doaj   +1 more source

Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis

Evolutionary Applications, 2022
For many clonally propagated species, the accumulation of somatic mutations is the principal driver of declines in yield and quality. However, somatic mutations may also promote genetic diversification.
Zeyu Zheng, Hongyin Hu, Weixiao Lei, Jin Zhang, Mingjia Zhu, Ying Li, Xu Zhang, Jianchao Ma, Dongshi Wan, Tao Ma, Guangpeng Ren, Dafu Ru   +11 more
doaj   +1 more source

Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics [PDF]

, 2023
Yuan Chun Ding, Hanbing Song, Aaron W. Adamson, Daniel Schmolze, Donglei Hu, Scott Huntsman, Linda Steele, Carmina S. Patrick, Shu Tao, Natalie Hernandez, Charleen D. Adams, Laura Fejerman, Kevin Gardner, Anna María Nápoles, Eliseo J. Pérez‐Stable, Jeffrey N. Weitzel, Henrik Bengtsson, Franklin W. Huang, Susan L. Neuhausen, Elad Ziv   +19 more
openalex   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Typing tumors using pathways selected by somatic evolution. [PDF]

, 2018
Many recent efforts to analyze cancer genomes involve aggregation of mutations within reference maps of molecular pathways and protein networks. Here, we find these pathway studies are impeded by molecular interactions that are functionally irrelevant to
Huang, Justin, Ideker, Trey, Ma, Jianzhu, Peng, Jian, Shen, John Paul, Wang, Sheng, Zhang, Wei   +6 more
core   +3 more sources

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

Nature, 2017
Somatic cells acquire mutations throughout the course of an individual’s life. Mutations occurring early in embryogenesis are often present in a substantial proportion of, but not all, cells in postnatal humans and thus have particular characteristics ...
Y. Ju, I. Martincorena, M. Gerstung, Mia Petljak, Ludmil B. Alexandrov, R. Rahbari, D. Wedge, Helen R Davies, Manasa Ramakrishna, A. Fullam, Sancha Martin, Christopher Alder, Nikita Patel, Stephen J. Gamble, S. O’Meara, D. Giri, Torril Sauer, S. Pinder, C. Purdie, Å. Borg, H. Stunnenberg, M. J. van de Vijver, B. Tan, C. Caldas, A. Tutt, N. Ueno, L. V. van’t Veer, J. Martens, C. Sotiriou, S. Knappskog, P. Span, S. Lakhani, J. Eyfjörd, A. Børresen-Dale, A. Richardson, A. Thompson, A. Viari, M. Hurles, S. Nik-Zainal, P. Campbell, M. Stratton   +40 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

CLINICAL IMPLICATIONS OF COPY NUMBER ALTERATION DETECTION USING PANEL-BASED NEXT-GENERATION SEQUENCING DATA IN MYELODYSPLASTIC SYNDROME

Leukemia Research Reports
Introduction: Recurrent somatic mutations are found in about 90 % of the MDS patients, and some of the mutations are known to have a prognostic value at various clinical stages of myelodysplastic syndrome (MDS).
S.-H. Jung, Y.-J. Chung
doaj   +1 more source