Results 101 to 110 of about 1,061,050 (301)

Assessing the role of serum prolactin levels and coding region somatic mutations of the prolactin gene in Saudi uterine leiomyoma patients

, 2020
Introduction Uterine leiomyomas (UL) are highly prevalent benign smooth muscle tumors, seen in approximately 70% of women. These hormone responsive tumors are also known to secrete prolactin (PRL), a hormone of the anterior pituitary gland.
Layla Saleh Abdullah, Nabeel Bondagji, Amani Ujaimi, Babajan Banaganapalli, Ramu Elango, Elango, Ramu, Nora Naif Sahly, Shaik, Noor Ahmad, ElSokary, Hanan Abdelhalim, Ujaimi, Amani, Noor Ahmad Shaik, Hanan Abdelhalim ElSokary, Banaganapalli, Babajan, Sahly, Nora Naif, Bondagji, Nabeel, Mansouri, Nisma, Abdullah, Layla Saleh, Nisma Mansouri   +17 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia

, 2008
PURPOSE: The transcription factor CCAAT/enhancer binding protein-alpha (CEBPA) is crucial for normal myeloid differentiation. Mutations in the CEBPA gene are found in subsets of patients with acute myeloid leukemia (AML).
Schardt, Julian, Pabst, Thomas, Haefliger, Simon, Mueller, Beatrice U, Eyholzer, Marianne, Eyholzer M, Schardt J, Pabst, Thomas Niklaus, Mueller BU, Müller, Beatrice Ursula, Pabst T, Haefliger S, Mueller, Beatrice U.   +12 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Somatic Mutations in Single Neurons

, 2017
Somatic mutations occur during brain development and are increasingly implicated as a cause of neurogenetic disease. However, the frequency and patterns of somatic mutations in the human brain have not been explored in detail.
Lee, Semin
core  

Studies of JAK2 mutations in myeloproliferative disorders [PDF]

, 2008
Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Sanger-validated somatic mutations of CSMD1 in colorectal tumors.

, 2013
Sanger-validated somatic mutations of CSMD1 in colorectal tumors.
Austin Y. Shull (141749), Christopher L. Farrell (386323), Megan L. Clendenning (386321), Sampa Ghoshal-Gupta (386322), Larry Dudas (386325), Brent J. Wilkerson (386326), Hima V. Vangapandu (386324), Phillip J. Buckhaults (141767)   +7 more
core   +1 more source

Gene expression analyses on skin lesions from patients with familial adenomatous polyposis [PDF]

, 2014
Familial adenomatous polyposis coli (FAP) is an autosomal dominant colorectal cancer predisposition syndrome caused by germline mutations in the APC gene.
Stegmann, Danielle Alexandra
core   +1 more source