Results 81 to 90 of about 233,128 (302)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Characterizing somatic mutations in ovarian cancer germline risk regions

Communications Biology
Epithelial ovarian cancer (EOC) genetics research has been focused on germline or somatic mutations independently. Emerging evidence suggests that the somatic mutational landscape can be shaped by the germline genetic background. In this study, we aim to
Ping-Hung Lai, Jonathan P. Tyrer, Paul Pharoah, Simon A. Gayther, Michelle R. Jones, Pei-Chen Peng   +5 more
doaj   +1 more source

CLINICAL IMPLICATIONS OF COPY NUMBER ALTERATION DETECTION USING PANEL-BASED NEXT-GENERATION SEQUENCING DATA IN MYELODYSPLASTIC SYNDROME

Leukemia Research Reports
Introduction: Recurrent somatic mutations are found in about 90 % of the MDS patients, and some of the mutations are known to have a prognostic value at various clinical stages of myelodysplastic syndrome (MDS).
S.-H. Jung, Y.-J. Chung
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH

, 2002
Background & Aims: MUTYH-associated polyposis (MAP) is an autosomal recessive disorder caused by mutations in the MUTYH gene. Patients with MAP are at extremely high risk of colorectal cancer, but the risks of colorectal and other cancers in ...
Jones, Natalie, Maher, Eamonn, Sampson, Julian Roy, Edwards, Emma, Christian, Daria, Evans, D Gareth, Vasen, Hans F., Wark, Petra A., Sampson, Julian R, Eccles, Diana, Aretz, Stefan, Nielsen, Maartje, Maher, Eamonn R., Wark, Petra A, Vogt, Stefanie, Wark, Petra A.; id_orcid, Hes, Frederik J, Hes, Frederik J., Evans, D. Gareth, Sampson, Julian R., Vasen, Hans F, Maher, Eamonn R   +21 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dietary factors, genetic susceptibility and somatic mutations in colorectal cancer: a prospective study. [PDF]

, 2002
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de Goeij, AFPM, Weijenberg, M. P., Lüchtenborg, M., Goldbohm, R. A., Brandt, P.A. van den, Kampman, E, de Goeij, A F P M, de Bruïne, A P, Wark, PA, de Goeij, A. F., van den Brandt, P. A., Goldbohm, R.A., Goldbohm, RA, de Bruïne, A. P., van't Veer, P., Goldbohm, R A, Muijen, G.N.P. van, de Bruïne, AP, Weijenberg, MP, van't Veer, P, Wark, P A, Lüchtenborg, M, van den Brandt, P A, van Muijen, G. N., van 't Veer, C., Veer, P. van 't, van Muijen, GNP, van den Brandt, PA, Brink, M, Wark, P.A., van Muijen, G.N.P., Bruïne, A.P. de, Bausch-Goldbohm, R.A., van Muijen, G N P, Weijenberg, M P, Brink, M., van 't Veer, P., van den Brandt, P.A., Goeij, A.F.P.M. de, Goeij, A.F. de, de Bruine, A.P., Wark, P. A.; id_orcid, Weijenberg, M.P., Kampman, E., de Goeij, A.F.P.M.   +44 more
core  

Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer

BMC Cancer, 2006
Background The roles of mitochondria in energy metabolism, the generation of ROS, aging, and the initiation of apoptosis have implicated their importance in tumorigenesis. In this study we aim to establish the mutation spectrum and to understand the role
Wang Yu-Fen, Bai Ren-Kui, Liu Ling-Ling, Chang Julia, Tan Duan-Jun, Yeh Kun-Tu, Wong Lee-Jun C   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

BMC Cancer, 2019
Background Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the United States.
Tarun Karthik Kumar Mamidi, Jiande Wu, Chindo Hicks   +2 more
doaj   +1 more source