Results 111 to 120 of about 208,660 (254)

Linking somatic mutations in cancer to the electronic properties of DNA. [PDF]

BMC Genomics
de Witte B, Karamaoun C, Hermans P, Tarabichi M, Pucci F, Rooman M.   +5 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Somatic mutations distinguish melanocyte subpopulations in human skin. [PDF]

Nat Cell Biol
Tandukar B, Deivendran D, Chen L, Bahrani N, Baskurt D, Weier B, Sharma H, Cruz-Pacheco N, Hu M, Marks K, Zitnay RG, Bandari AK, Rentroia-Pacheco B, Nekoonam R, Bastian BC, Yeh I, Judson-Torres R, Shain AH.   +17 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis. [PDF]

JCI Insight
Rajeh A, Shahsavari S, Cornman H, Kollhoff A, Gupta A, Szeto MD, Kambala A, Oladipo OO, Parthasarathy V, Deng J, Marani M, Shahsavari S, Yossef SM, Vaddaraju V, Adawi W, Akiska YM, Gage DM, Wheelan S, Pritchard T, Kwatra MM, Semenov YR, Gusev A, Ho WJ, Yegnasubramanian S, Kwatra SG.   +24 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Somatic mutations and clonal evolution in normal tissues and cancer development. [PDF]

Exp Mol Med
Yoshida K.
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Sensitive detection of somatic mutations in GC-rich cancer gene promoters. [PDF]

NAR Cancer
Qi M, Dave PS, Francis N, DeFelice M, Pollock S, Corbitt H, Mitsiades IR, Wang G, Frere P, Fox A, Khitrov G, Petersen C, Larkin K, Hamilton S, Ellisen LW, Gulhan DC, Hidalgo-Miranda A, Lennon N, Cibulskis C, Rheinbay E.   +19 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source