Results 131 to 140 of about 199,006 (315)

SOMATIC MUTATIONAL TRANSIENTS. III. RESPONSE BY TWO GENES IN A CLONE OF NICOTIANA TO 24 ROENTGENS OF GAMMA RADIATION APPLIED AT VARIOUS INTENSITIES [PDF]

, 1973
Seaward A Sand, Harold H. Smith
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

STUDIES ON SOMATIC CELL MUTATIONS

, 1976
Sadayuki Ban, Fumio Suzuki, Masakatsu Horikawa   +2 more
openalex   +4 more sources

Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma [PDF]

, 1994
Simon D. Wagner, V Martinelli, Lucio Luzzatto   +2 more
openalex   +3 more sources

Bayesian Probit Multi-Study Non-negative Matrix Factorization for Mutational Signatures [PDF]

arXiv
Mutational signatures are patterns of somatic mutations in tumor genomes that provide insights into underlying mutagenic processes and cancer origin. Developing reliable methods for their estimation is of growing importance in cancer biology. Somatic mutation data are often collected for different cancer types, highlighting the need for multi-study ...
arxiv  

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

CLINICAL IMPLICATIONS OF COPY NUMBER ALTERATION DETECTION USING PANEL-BASED NEXT-GENERATION SEQUENCING DATA IN MYELODYSPLASTIC SYNDROME

Leukemia Research Reports
Introduction: Recurrent somatic mutations are found in about 90 % of the MDS patients, and some of the mutations are known to have a prognostic value at various clinical stages of myelodysplastic syndrome (MDS).
S.-H. Jung, Y.-J. Chung
doaj  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Genetic diversity within a tree and alternative indexes for different evolutionary effects

Quantitative Plant Biology
Trees, living for centuries, accumulate somatic mutations in their growing trunks and branches, causing genetic divergence within a single tree. Stem cell lineages in a shoot apical meristem accumulate mutations independently and diverge from each other.
Yoh Iwasa, Sou Tomimoto, Akiko Satake
doaj   +1 more source

Somatic Mutational Transients: Models of Response to Acute and Distributed Doses of Radiation Applied to Growing Plants [PDF]

, 1972
Seaward A Sand
openalex   +1 more source