Results 151 to 160 of about 1,861,621 (385)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Can somatic GATA2 mutation mimic germ line GATA2 mutation? [PDF]

, 2018
Mallika Sekhar, Rachael Pocock, David M. Lowe, Christopher Mitchell, Teresa Marafioti, Rachel Dickinson, Matthew Collin, Marc Lipman   +7 more
openalex   +1 more source

Whole-Exome Sequencing Study of Thyrotropin-Secreting Pituitary Adenomas [PDF]

, 2018
学位記番号 ...
Santosh, Sapkota, Santosh, Sapkota, サントス, サプコタ   +2 more
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Analysis ofFas/CD95 gene somatic mutations in ovarian cancer cell lines [PDF]

, 2000
Francesco Bertoni, Annarita Conconi, Stefania Carobbio, Claudio Realini, Anna Maria Codegoni, Emanuele Zucca, Franco Cavalli   +6 more
openalex   +1 more source

Data from Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers

, 2023
Jintao Guo, Ying Zhou, Chaoqun Xu, Qinwei Chen, Zsófia Sztupinszki, Judit Börcsök, Canqiang Xu, Feng Ye, Weiwei Tang, Jiapeng Kang, Lu Yang, Jiaxin Zhong, Taoling Zhong, Tianhui Hu, Rongshan Yu, Zoltán Szállási, Xianming Deng, Qiyuan Li   +17 more
openalex   +1 more source

Non-invasive detection of somatic mutations using next-generation sequencing in primary central nervous system lymphoma

OncoTarget, 2017
Purpose Primary central nervous system lymphomas (PCNSL) have recurrent genomic alterations. The main objective of our study was to demonstrate that targeted sequencing of circulating cell-free DNA (cfDNA) released by PCNSL at the time of diagnosis could
M. Fontanilles, F. Marguet, É. Bohers, P. Viailly, S. Dubois, P. Bertrand, V. Camus, S. Mareschal, P. Ruminy, C. Maingonnat, S. Leprêtre, E. Veresezan, S. Derrey, H. Tilly, J. Picquenot, A. Laquérriere, F. Jardin   +16 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Supplementary Figure S5 from Evaluation of Somatic Mutations in Urine Samples as a Noninvasive Method for the Detection and Molecular Classification of Endometrial Cancer

, 2023
Laura Costas, Irene Onieva, Beatriz Pelegrina, Fátima Marín, Álvaro Carmona, Marta López-Querol, Jon Frias‐Gomez, Paula Peremiquel‐Trillas, José Manuel Martínez, Eduard Dorca, Joan Brunet, Marta Pineda, Jordi Ponce, Xavier Matías‐Guiu, Sílvia de Sanjosé, F. Xavier Bosch, Laia Alemany, Sònia Paytubi   +17 more
openalex   +1 more source