Results 191 to 200 of about 199,006 (315)

Analysis of endometrial liquid‑based cytology samples to detect somatic mutations and classify ovarian cancer. [PDF]

Oncol Lett
Kubo-Kaneda M, Kondo E, Nimura R, Okamoto K, Matsumoto T, Yoshida K, Ikejiri M, Nakamura M, Imai H, Okugawa Y, Nakatani K, Ikeda T.   +11 more
europepmc   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Functional annotation of the Hippo pathway somatic mutations in human cancers. [PDF]

Nat Commun
Han H, Huang Z, Xu C, Seo G, An J, Yang B, Liu Y, Lan T, Yan J, Ren S, Xu Y, Xiao D, Yan JK, Ahn C, Fishman DA, Meng Z, Guan KL, Qi R, Luo R, Wang W.   +19 more
europepmc   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

Preliminary identification of somatic mutations profile in ACL injury. [PDF]

Sci Rep
Zhu X, Sun S, Yao Y, Jiang F, Yang F, Zhao H, Xue Z, Dai S, Yu T, Xiao X.   +9 more
europepmc   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology. [PDF]

Nat Commun
Zhang Y, Leung AK, Kang JJ, Sun Y, Wu G, Li L, Sun J, Cheng L, Qiu T, Zhang J, Wierbowski SD, Gupta S, Booth JG, Yu H.   +13 more
europepmc   +1 more source

Synergistic effects of methyl methanesulfonate and X rays in inducing somatic mutations in the stamen hairs of Tradescantia clones, KU 27 and BNL 4430.

, 1993
Sadao Ichikawa, Akihiko Yamaguchi, Mikiko Okumura   +2 more
openalex   +2 more sources

High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia [PDF]

, 1996
Frédéric Davi, Karim Maloum, A Michel, Otto Pritsch, Christian Magnac, Elizabeth Macintyre, Florence Nguyen‐Khac, JL Binet, Guillaume Dighiero, Hélène Merle‐Béral   +9 more
openalex   +1 more source

Engineering Magnetotactic Bacteria as Medical Microrobots

Advanced Materials, EarlyView.
Magnetotactic bacteria (MTB) are living microorganisms that produce magnetosomes for navigation using the Earth's geomagnetic field. Their built‐in magnetic components, along with their intrinsic and/or modified biological functions, make them one of the most promising platforms for making future living and programmable microrobots.
Jiaqi Wang, Yi Xing, Michael Ngatio, Paulina Bies, Lu Lucy Xu, Liuxi Xing, Ahmed Zarea, Ashley V. Makela, Christopher H. Contag, Jinxing Li   +9 more
wiley   +1 more source