Results 221 to 230 of about 1,861,621 (385)

Quantitative and sensitive sequencing of somatic mutations induced by a maize transposon [PDF]

Jessica Scherer, Michael Hinczewski, Brad Nelms   +2 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency. [PDF]

Front Genet
Sajjad M, Kwon SG.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Somatic Mutations of Thymic Epithelial Tumors Identified in the Prospective THYMOGENE Trial. [PDF]

Thorac Cancer
Pardini E, Cucchiara F, Barachini S, Montali M, Sardo Infirri G, Burzi IS, Maestri M, Guida M, Ricciardi R, Nicolì V, Coppedè F, Bacchin D, Zafira CC, Aprile V, Melfi F, Lucchi M, Petrini I.   +16 more
europepmc   +1 more source

Somatic mutations of calreticulin in myeloproliferative neoplasms.

New England Journal of Medicine, 2013
T. Klampfl, H. Gisslinger, A. Harutyunyan, Harini Nivarthi, E. Rumi, J. Milosevic, Nicole C. C. Them, T. Berg, B. Gisslinger, D. Pietra, Doris Chen, G. Vladimer, K. Bagienski, C. Milanesi, I. Casetti, Emanuela Sant'Antonio, V. Ferretti, C. Elena, Fiorella Schischlik, Ciara Cleary, M. Six, M. Schalling, Andreas Schönegger, C. Bock, L. Malcovati, C. Pascutto, G. Superti-Furga, M. Cazzola, R. Kralovics   +28 more
semanticscholar   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Identification of novel germline and somatic mutations associated with hepatocellular carcinoma by next-generation sequencing. [PDF]

Front Pharmacol
Laaribi AB, Babay W, Lekired A, Bouchabou B, Mehri A, Bacha D, Sassi R, Ben Slama S, Bayar R, Omrani S, Boujelbene N, Ennaifer R, Arfa N, Lahmar A, Ouzari HI.   +14 more
europepmc   +1 more source

Association of p53-autoantibodies with TP53 somatic mutational profile detected by next generation sequencing in advanced high-grade ovarian cancer [PDF]

, 2017
Marica Garziera, Erika Cecchin, Jerry Polesel, Rossana Roncato, Sara Gagno, Elena De Mattia, Roberto Sorio, Simona Scalone, Elena Poletto, Giuseppe Toffoli   +9 more
openalex   +1 more source

Integrating Somatic Mutations for Breast Cancer Survival Prediction Using Machine Learning Methods

, 2021
Zongzhen He, Junying Zhang, Xiguo Yuan, Yuanyuan Zhang   +3 more
openalex   +1 more source