Results 241 to 250 of about 1,061,050 (301)

Real-World Outcomes of Adjuvant Therapy in Stage III Melanoma and the Impact of Somatic Mutations. [PDF]

Cancer Med
Effiom D, Aprati T, Karneris A, Lawless A, Sharova T, Johnson R, Menzies A, Long G, Park B, Jung S, Johnson D, Liu D, Bai X, Flaherty K, Sullivan R, Boland GM, Cohen S.   +16 more
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CDKN2A homozygous deletions and TSC2 somatic mutations in metastatic pancreatic neuroendocrine tumors. [PDF]

NPJ Precis Oncol
Jesus TT, Ferrando L, Rodrigues L, Martins RS, Cardoso L, Lopes JM, Soares P, Da Cruz Paula A, Vinagre J.   +8 more
europepmc   +1 more source

Correction: Somatic mutations in the TG and RELA genes specific for radioiodine-refractory thyroid cancer. [PDF]

Sci Rep
Sukprakun C, Nuwongsri P, Tongkobpetch S, Srichomthong C, Vinayanuwattikun C, Keelawat S, Jantasuwan S, Tangjaturonrasme N, Samorn P, Shotelersuk V, Tepmongkol S.   +10 more
europepmc   +1 more source

Analysis of Somatic Mutations and Immunotherapy Biomarkers in Chinese Patients With Non-Small Cell Lung Cancer During 2019-2024: A Retrospective Study. [PDF]

Health Sci Rep
Liu X, Chen W, Xin C, Wang Z, Yi K, Wang L, Liu J.   +6 more
europepmc   +1 more source

Associations of tumour somatic mutations with cancer-associated venous thromboembolism

Cornish N, Ward R, Warkentin MT, Thirlwell C, Mumford AD, Westbury SK, Haycock PC.   +6 more
europepmc   +1 more source

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Somatic Mutations and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2022
Alzheimer’s disease (AD) represents a global health challenge, with an estimated 55 million people suffering from the non-curable disease across the world. While amyloid-β plaques and tau neurofibrillary tangles in the brain define AD proteinopathy, it has become evident that diverse coding and non-coding regions of the genome may significantly ...
Jocelyn, Downey, Jacqueline C K, Lam, Victor O K, Li, Illana, Gozes   +3 more
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Somatic Mutation and Aging

Annals of the New York Academy of Sciences, 1998
ABSTRACT: A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age.
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Somatic mutations and proteins

Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966
Abstract A large body of data has now been accumulated concerning the ways in which heritable mutations can affect protein structure. Such mutations are usually presumed to arise in the germ line, and are studied by progeny analyses of various types.
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Somatic mutation theory

Journal of Toxicology and Environmental Health, 1980
The evidence is reviewed that supports the role of genetic lesions in carcinogenesis; such lesions may be initiating events in the multistep process leading to clinically detectable tumor. Other possible manifestations of alterations in the hereditary material of somatic cells are discussed; DNA damage may lead to benign tumors responsible for ...
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Somatic mutation and memory

Current Opinion in Immunology, 1993
The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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