Results 241 to 250 of about 233,128 (302)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Dwarfism in Pinus taeda originates from independent somatic mutations co-localized in a shared genomic region. [PDF]

Heredity (Edinb)
Guner P, Shalizi MN, Isik F, Walker TD.
europepmc   +1 more source

Association between ancestry and tumor somatic mutations in a large national cohort of women with breast cancer. [PDF]

NPJ Breast Cancer
Fergus KB, Newberg J, Greenstein R, Fejerman L, Carvajal-Carmona L, Collisson E, Dixit N, Frampton G, Huang FW, Neuhausen SL, Ziv E.   +10 more
europepmc   +1 more source

The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions. [PDF]

Cancer Res Commun
Hayashi A, Ho YJ, Makohon-Moore AP, Zucker A, Hong J, Umeda S, Karnoub ER, Huang J, Baez P, Kappagantula R, Melchor JP, Park W, O'Reilly EM, Socci ND, Oki S, Iacobuzio-Donahue CA.   +15 more
europepmc   +1 more source

Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review. [PDF]

Oncologist
Abujamous L, Ahmed I, Ahen Y, Alotaibi H, Al Moustafa AE, Mohd Arif S, Al-Thawadi H, Razali R.   +7 more
europepmc   +1 more source

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Somatic mutations and ageing in silico

Mechanisms of Ageing and Development, 2003
Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with a dynamic profile that is ...
Carole J Proctor
exaly   +4 more sources

Fitness effects of somatic mutations accumulating during vegetative growth

Evolutionary Ecology, 2022
The unique life form of plants promotes the accumulation of somatic mutations that can be passed to offspring in the next generation, because the same meristem cells responsible for vegetative growth also generate gametes for sexual reproduction. However,
Mitchell B Cruzan, Matthew A Streisfeld
exaly   +3 more sources

Somatic Mutations and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2022
Alzheimer’s disease (AD) represents a global health challenge, with an estimated 55 million people suffering from the non-curable disease across the world. While amyloid-β plaques and tau neurofibrillary tangles in the brain define AD proteinopathy, it has become evident that diverse coding and non-coding regions of the genome may significantly ...
Jocelyn, Downey, Jacqueline C K, Lam, Victor O K, Li, Illana, Gozes   +3 more
openaire   +2 more sources