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Somatic Mutation and Antibody Diversity
Survey and Synthesis of Pathology Research, 2008Nucleotide insertions or deletions determine novel amino acid sequences at the VH-D and D-JH junction sites. Since these cannot be predicted by known coding genes, they are regarded as a form of somatic mutagenesis. A second type of somatic mutation in Ig structural genes are the stochastic base substitutions that have now been found in both V region ...
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Somatic Mutations in Aplastic Anemia
Hematology/Oncology Clinics of North America, 2018Aplastic anemia (AA) is an immune-mediated disorder that overlaps closely with clonal disorders, such as myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria (PNH). PIGA mutations in PNH clones and functional loss of HLA, including structural HLA mutations, likely represent immune escape clones and correlate with response to ...
Mufti, Ghulam J., Marsh, Judith C.W.
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2017
Somatic mutations in patient tumor DNA samples can be readily detected based on mass spectrometry. The MassARRAY system is a high-throughput matrix-assisted laser desorption time-of-flight (MALDI) mass spectrometer for detection of nucleic acids. The technique is based on single-nucleotide base extension.
Anthony, O'Grady, Robert, Cummins
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Somatic mutations in patient tumor DNA samples can be readily detected based on mass spectrometry. The MassARRAY system is a high-throughput matrix-assisted laser desorption time-of-flight (MALDI) mass spectrometer for detection of nucleic acids. The technique is based on single-nucleotide base extension.
Anthony, O'Grady, Robert, Cummins
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Somatic mutations in aging and disease
GeroScienceTime always leaves its mark, and our genome is no exception. Mutations in the genome of somatic cells were first hypothesized to be the cause of aging in the 1950s, shortly after the molecular structure of DNA had been described. Somatic mutation theories of aging are based on the fact that mutations in DNA as the ultimate template for all cellular ...
Peijun Ren, Jie Zhang, Jan Vijg
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Neonatal Immunity and Somatic Mutation
International Reviews of Immunology, 2000Neonatal animals are able to mount an effective immune response, both humoral and cellular, when immunized using conditions that maximize stimulation of antigen presenting cells, T cells, and B cells. In adults, somatic mutation is a key feature of the humoral immune response because it contributes to the generation of high affinity memory B cells ...
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Low-Level Brain Somatic Mutations Are Implicated in Schizophrenia
Biological Psychiatry, 2021Myeong-Heui Kim +2 more
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Somatic Mutations in “Benign” Disease
New England Journal of Medicine, 2021Osama, Dasa, Thomas A, Pearson
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Somatic mutations in rheumatological diseases: VEXAS syndrome and beyond
Rheumatology, 2022Peter C Grayson +2 more
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