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Somatic mutations in aging and disease
GeroScienceTime always leaves its mark, and our genome is no exception. Mutations in the genome of somatic cells were first hypothesized to be the cause of aging in the 1950s, shortly after the molecular structure of DNA had been described. Somatic mutation theories of aging are based on the fact that mutations in DNA as the ultimate template for all cellular ...
Peijun Ren, Jie Zhang, Jan Vijg
openaire +2 more sources
Somatic Mutations in “Benign” Disease
New England Journal of Medicine, 2021Osama, Dasa, Thomas A, Pearson
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Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging
Cell, 2020Xiao Dong, Jan Vijg
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Somatic Mutations Provide Important and Unique Insights Into the Biology of Complex Diseases
Trends in Genetics, 2021Carl A Anderson
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Brain Somatic Mutation in Aging and Alzheimer's Disease
Annual Review of Genomics and Human Genetics, 2021Christopher A. Walsh
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