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Annals of the New York Academy of Sciences, 1998
ABSTRACT: A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age.
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ABSTRACT: A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age.
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Somatic mutations and proteins
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966Abstract A large body of data has now been accumulated concerning the ways in which heritable mutations can affect protein structure. Such mutations are usually presumed to arise in the germ line, and are studied by progeny analyses of various types.
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Journal of Toxicology and Environmental Health, 1980
The evidence is reviewed that supports the role of genetic lesions in carcinogenesis; such lesions may be initiating events in the multistep process leading to clinically detectable tumor. Other possible manifestations of alterations in the hereditary material of somatic cells are discussed; DNA damage may lead to benign tumors responsible for ...
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The evidence is reviewed that supports the role of genetic lesions in carcinogenesis; such lesions may be initiating events in the multistep process leading to clinically detectable tumor. Other possible manifestations of alterations in the hereditary material of somatic cells are discussed; DNA damage may lead to benign tumors responsible for ...
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Current Opinion in Immunology, 1993
The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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Review: Somatic mutations in neurodegeneration
Neuropathology and Applied Neurobiology, 2018Somatic mutations are postzygotic mutations which may lead to mosaicism, the presence of cells with genetic differences in an organism. Their role in cancer is well established, but detailed investigation in health and other diseases has only been recently possible.
M. Leija‐Salazar +2 more
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Problems of somatic mutation and cancer
BioEssays, 2004AbstractSomatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a ...
Steven A, Frank, Martin A, Nowak
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Evidence of somatic mutations in osteoarthritis
Human Genetics, 1996We examined, cytogenetically and by in situ hybridization (ISH) techniques, the synovia, osteophytes, and articular cartilage from 32 patients with pronounced osteoarthritis (OA), a prevalent form of arthropathy characterized by progressive reduction of articular cartilage, and synovial samples from 17 control patients.
F, Mertens +9 more
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Somatic Mutation in the Neonatal Mouse
The Journal of Immunology, 1998Abstract Several mechanisms that diversify the adult immune repertoire, such as terminal deoxynucleotidyl transferase-dependent N region addition, are not available to the neonatal mouse. One important process that contributes to protective immunity in the adult is somatic mutation, which plays a major role in the generation of high ...
C A, Giorgetti, J L, Press
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Somatic mutations and the hierarchy of hematopoiesis
BioEssays, 2010AbstractClonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCR‐ABL, characteristic of chronic myeloid ...
Traulsen, A. +3 more
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Germline and somatic mutations in meningiomas
Cancer Genetics, 2015Meningiomas arise from the arachnoid layer of the meninges that surround the brain and spine. They account for over one third of all primary central nervous system tumors in adults and confer a significant risk of location-dependent morbidity due to compression or displacement.
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