Results 41 to 50 of about 199,006 (315)
Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis [PDF]
Royal Society Open Science, 2, 150143, 2015, 2015 The Kolmogorov-Arnold stochasticity parameter technique is applied for the first time to the study of cancer genome sequencing, to reveal mutations. Using data generated by next generation sequencing technologies, we have analyzed the exome sequences of brain tumor patients with matched tumor and normal blood.
arxiv +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer
Prostate Cancer, 2019 Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA. Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of ...
Tarun Karthik Kumar Mamidi +2 more
doaj +1 more source
Aging and the rise of somatic cancer-associated mutations in normal tissues. [PDF]
PLoS Genetics, 2018 DNA mutations are inevitable. Despite proficient DNA repair mechanisms, somatic cells accumulate mutations during development and aging, generating cells with different genotypes within the same individual, a phenomenon known as somatic mosaicism.
Rosa Ana Risques, Scott R Kennedy
doaj +1 more source
Comprehensive Study of Germline Mutations and Double-Hit Events in Esophageal Squamous Cell Cancer
Frontiers in Oncology, 2021 Esophageal squamous cell cancer (ESCC) is the eighth most common cancer around the world. Several reports have focused on somatic mutations and common germline mutations in ESCC.
Bing Zeng +9 more
doaj +1 more source
A flexible model-based framework for robust estimation of mutational signatures [PDF]
arXiv, 2022 Somatic mutations in cancer can be viewed as a mixture distribution of several mutational signatures, which can be inferred using non-negative matrix factorization (NMF). Mutational signatures have previously been parametrized using either simple mono-nucleotide interaction models or general tri-nucleotide interaction models. We describe a flexible and
arxiv
Using somatic mutation data to test tumors for clonal relatedness [PDF]
Annals of Applied Statistics 2015, Vol. 9, No. 3, 1533-1548, 2015 A major challenge for cancer pathologists is to determine whether a new tumor in a patient with cancer is a metastasis or an independent occurrence of the disease. In recent years numerous studies have evaluated pairs of tumor specimens to examine the similarity of the somatic characteristics of the tumors and to test for clonal relatedness.
arxiv +1 more source
Somatic mutation in biologic research1 [PDF]
Hereditas, 2009 In the last few years rapid progress has been made in several laboratories in the area of a possible etiologic role of somatic mutation in carcinogenesis and aging. Studies such as metabolic activation of an initial carcinogen to its active form, the genetic effects of tumor viruses, studies of DNA repair mechanisms, specific chromosomal patterns ...
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
International Journal of Genomics, 2020 Background. Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations ...
Jiande Wu +3 more
doaj +1 more source