Results 21 to 30 of about 233,128 (302)
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.
PLoS Genetics, 2014 The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging and common diseases of the elderly, including cancer and neurodegenerative disease. However, the mechanisms that influence the frequency of somatic mtDNA mutations are
Leslie S Itsara +7 more
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Confidence-based somatic mutation evaluation and prioritization.
PLoS Computational Biology, 2012 Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms.
Martin Löwer +12 more
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Somatic Mutations in Fruit Trees: Causes, Detection Methods, and Molecular Mechanisms
Plants, 2023 Somatic mutations are genetic changes that occur in non-reproductive cells. In fruit trees, such as apple, grape, orange, and peach, somatic mutations are typically observed as “bud sports” that remain stable during vegetative propagation.
Seunghyun Ban, Je Hyeong Jung
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Studies of JAK2 mutations in myeloproliferative disorders [PDF]
, 2008 Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
core +1 more source
QuaDMutEx: quadratic driver mutation explorer
BMC Bioinformatics, 2017 Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells ...
Yahya Bokhari, Tomasz Arodz
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PLoS Genetics, 2022 Most somatic mutations that arise during normal development are present at low levels in single or multiple tissues depending on the developmental stage and affected organs.
Ja Hye Kim +12 more
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Comparison of Germline versus Somatic BAP1 Mutations for Risk of Metastasis in Uveal Melanoma
BMC Cancer, 2018 Background Germline mutations in BAP1 have been associated with BAP1-Tumor Predisposition Syndrome (BAP1-TPDS), a predisposition to multiple tumors within a family that includes uveal melanoma (UM), cutaneous melanoma, malignant mesothelioma and renal ...
K. G. Ewens +4 more
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Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples
BMC Bioinformatics, 2018 Background Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations.
Ivan P. Gorlov +9 more
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Germline and somatic mtDNA mutations in mouse aging. [PDF]
PLoS ONE, 2018 The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans.
Hong Ma +14 more
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