Results 41 to 50 of about 1,061,050 (301)

Uncovering the profile of somatic mtDNA mutations in Chinese colorectal cancer patients. [PDF]

PLoS ONE, 2011
In the past decade, a high incidence of somatic mitochondrial DNA (mtDNA) mutations has been observed, mostly based on a fraction of the molecule, in various cancerous tissues; nevertheless, some of them were queried due to problems in data quality ...
Cheng-Ye Wang, Hui Li, Xiao-Dan Hao, Jia Liu, Jia-Xin Wang, Wen-Zhi Wang, Qing-Peng Kong, Ya-Ping Zhang   +7 more
doaj   +1 more source

Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1. [PDF]

PLoS ONE, 2017
The growth behaviors of cutaneous neurofibromas in patients with Neurofibromatosis type 1 are highly variable. The role of the germline NF1 mutation, somatic NF1 mutation and mutations at modifying loci, are poorly understood.
Daniel L Faden, Saurabh Asthana, Tarik Tihan, Joseph DeRisi, Michel Kliot   +4 more
doaj   +1 more source

Potential immunosuppressive clonal hematopoietic mutations in tumor infiltrating immune cells in breast invasive carcinoma

Scientific Reports, 2023
A hallmark of cancer is a tumor cell’s ability to evade immune destruction. Somatic mutations in tumor cells that prevent immune destruction have been extensively studied.
Ramu Anandakrishnan, Ian J. Zyvoloski, Lucas R. Zyvoloski, Nana K. Opoku, Andrew Dai, Veneeth Antony   +5 more
doaj   +1 more source

Sanger sequencing validated somatic mutations.

, 2015
A, somatic mutations which had been reported in CRC or other cancers. B, novel somatic mutations that discovered in our CRC patients.
Zheng Wang (25883), Wei-Dong Li (223291), Chao Ling (418561), Lifang Sun (125709), Lin Wang (11986), Kai Wang (21246), Luming Xu (686027), Hui Yang (91136)   +7 more
core   +1 more source

Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data

Frontiers in Aging, 2022
Somatic mutations are DNA variants that occur after the fertilization of zygotes and accumulate during the developmental and aging processes in the human lifespan.
August Yue Huang, Eunjung Alice Lee
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Prostate Cancer, 2019
Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA. Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of ...
Tarun Karthik Kumar Mamidi, Jiande Wu, Chindo Hicks   +2 more
doaj   +1 more source

Somatic mutations in children with GATA2-associated myelodysplastic syndrome who lack other features of GATA2 deficiency

Blood Advances, 2017
: Approximately 10% of children with primary myelodysplastic syndrome (MDS) have germ line GATA2 mutations, leading to the proposal that all children with primary MDS and certain cytogenetic findings, including monosomy 7, be tested for germ line GATA2 ...
Kevin E. Fisher, Amy P. Hsu, Christopher L. Williams, Hadi Sayeed, Brian Y. Merritt, M. Tarek Elghetany, Steven M. Holland, Alison A. Bertuch, Maria Monica Gramatges   +8 more
doaj   +1 more source

Delineation of the Germline and Somatic Mutation Interaction Landscape in Triple-Negative and Non-Triple-Negative Breast Cancer

International Journal of Genomics, 2020
Background. Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations ...
Jiande Wu, Tarun K. K. Mamidi, Lu Zhang, Chindo Hicks   +3 more
doaj   +1 more source

Aging and the rise of somatic cancer-associated mutations in normal tissues. [PDF]

PLoS Genetics, 2018
DNA mutations are inevitable. Despite proficient DNA repair mechanisms, somatic cells accumulate mutations during development and aging, generating cells with different genotypes within the same individual, a phenomenon known as somatic mosaicism.
Rosa Ana Risques, Scott R Kennedy
doaj   +1 more source