Results 131 to 140 of about 1,398 (171)
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Metabolism: Clinical and Experimental, 1985
Diabetes is associated with poor growth despite elevated levels of growth hormone (GH). Skeletal GH effects are mediated by somatomedins; in diabetes, somatomedins measured by radioassay are normal, yet somatomedin activity measured by bioassay is low. Since bioassay measurements reflect the presence of both somatomedins and somatomedin inhibitors, we ...
Lawrence S Phillips, Terry G Unterman
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Diabetes is associated with poor growth despite elevated levels of growth hormone (GH). Skeletal GH effects are mediated by somatomedins; in diabetes, somatomedins measured by radioassay are normal, yet somatomedin activity measured by bioassay is low. Since bioassay measurements reflect the presence of both somatomedins and somatomedin inhibitors, we ...
Lawrence S Phillips, Terry G Unterman
exaly +3 more sources
Nutrition, somatomedins, and the brain
Metabolism: Clinical and Experimental, 1986Conditions of decreased nutrient supply (malnutrition) and/or decreased nutrient utilization (diabetes) are attended by impairment of growth despite an increase in circulating levels of growth hormone (GH). Growth involves the actions of somatomedins, circulating insulinlike polypeptides with anabolic effects on cartilage, fat, and muscle.
Lawrence S Phillips
exaly +3 more sources
Radioimmunoassay of Somatomedin B
1975Publisher Summary This chapter provides an overview of radioimmunoassay of somatomedin B. The sensitivity of the assay permits the measurement of this factor in human plasma diluted 1:20,000 and in monkey plasma diluted 1:5000. Somatomedin B is not detected in many nonprimate plasmas diluted 1:20.
R S, Yalow, K, Hall, R, Luft
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Endocrinology, 1979
Although serum from normal rats has somatomedin (cartilage-stimulating) activity, serum from diabetic rats often lacks somatomedin activity and can inhibit somatomedin activity when added to serum from normal rats; this is attributed to somatomedin inhibitor (s).
L S, Phillips +3 more
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Although serum from normal rats has somatomedin (cartilage-stimulating) activity, serum from diabetic rats often lacks somatomedin activity and can inhibit somatomedin activity when added to serum from normal rats; this is attributed to somatomedin inhibitor (s).
L S, Phillips +3 more
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THE LIVER AS A SOURCE OF SOMATOMEDIN
Acta Endocrinologica, 1976ABSTRACT Somatomedin (Sm) activity (measured by [35S] uptake in chick embryo cartilage) was determined in serum samples simultaneously drawn from the hepatic vein, portal vein, femoral artery and femoral vein of seventeen anaesthezied normal adult dogs). A pool of human serum was taken as reference (Sm = 1 U/ml).
R M, Schimpff +4 more
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Metabolism, 1989
Circulating somatomedin activity reflects the presence of both somatomedins and somatomedin inhibitors, factors which antagonize the growth-promoting actions of somatomedins. Although both are regulated by nutrition, somatomedin inhibitors respond more rapidly than somatomedins to refeeding in fasted animals.
S, Goldstein, L S, Phillips
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Circulating somatomedin activity reflects the presence of both somatomedins and somatomedin inhibitors, factors which antagonize the growth-promoting actions of somatomedins. Although both are regulated by nutrition, somatomedin inhibitors respond more rapidly than somatomedins to refeeding in fasted animals.
S, Goldstein, L S, Phillips
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Wiener klinische Wochenschrift, 1987
Somatomedins are peptide hormones with insulin-like structure and effects. Their synthesis is governed by growth hormone. Somatomedins stimulate growth of cartilage tissue and other tissues. Synthesis of somatomedins occurs in various tissues, predominantly in the liver.
M B, Ranke, W, Blum, J R, Bierich
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Somatomedins are peptide hormones with insulin-like structure and effects. Their synthesis is governed by growth hormone. Somatomedins stimulate growth of cartilage tissue and other tissues. Synthesis of somatomedins occurs in various tissues, predominantly in the liver.
M B, Ranke, W, Blum, J R, Bierich
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Growth Hormone and Somatomedin
1974Publisher Summary This chapter provides an overview of the growth hormone and somatomedin. It is well established that growth hormone in vivo promotes skeletal growth and protein synthesis. Growth hormone promotes protein synthesis by stimulating the appearance in the tissues of a secondary factor, sulfation factor or somatomedin, which transfers ...
K, Hall, R, Luft
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Purification of bovine somatomedin
Biochemical and Biophysical Research Communications, 1975Abstract A procedure for the purification of bovine somatomedin (SM 4 ) is presented. The purification scheme utilizes ultrafiltration through membranes of nominal mol. wt. cutoffs, molecular sieve chromatography and finally iso-electric focusing.
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Molecular and Cellular Endocrinology, 1984
The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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