Results 131 to 140 of about 1,513 (164)

Normal Somatomedin and Somatomedin Receptors in Achondroplastic Dwarfism

Hormone and Metabolic Research, 1980
It has been proposed that the basic abnormality in achondroplasia may be a quantitative defect in endochondral new bone formation secondary to decreased synthesis of somatomedin (SM) or abnormal binding of SM to specific receptors. To test this hypothesis, we have measured plasma SM levels and SM receptors on circulating mononuclear cells obtained from
R G, Rosenfeld, R L, Hintz
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A SIMPLIFIED ASSAY FOR SOMATOMEDIN

Journal of Endocrinology, 1972
Abstract A simplified assay for somatomedin (sulphation factor; Daughaday, Hall, Raben, Salmon, Van den Brande & Van Wyk, 1972) is described in which the most time consuming steps have been eliminated without loss of precision or reliability. Twenty-two- to twenty-seven-day-old intact male Sprague-Dawley rats are
F P, Alford, J T, Bellair, H G, Burger, N, Lovett   +3 more
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Nutrition and Somatomedin. VI. Somatomedin Activity and Somatomedin Inhibitory Activity in Sera from Normal and Diabetic Rats*

Endocrinology, 1979
Although serum from normal rats has somatomedin (cartilage-stimulating) activity, serum from diabetic rats often lacks somatomedin activity and can inhibit somatomedin activity when added to serum from normal rats; this is attributed to somatomedin inhibitor (s).
L S, Phillips, D C, Belosky, H S, Young, L A, Reichard   +3 more
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Nutrition and somatomedin: Nutritionally regulated release of somatomedins and somatomedin inhibitors from perfused livers in rats

Metabolism, 1989
Circulating somatomedin activity reflects the presence of both somatomedins and somatomedin inhibitors, factors which antagonize the growth-promoting actions of somatomedins. Although both are regulated by nutrition, somatomedin inhibitors respond more rapidly than somatomedins to refeeding in fasted animals.
S, Goldstein, L S, Phillips
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THE LIVER AS A SOURCE OF SOMATOMEDIN

Acta Endocrinologica, 1976
ABSTRACT Somatomedin (Sm) activity (measured by [35S] uptake in chick embryo cartilage) was determined in serum samples simultaneously drawn from the hepatic vein, portal vein, femoral artery and femoral vein of seventeen anaesthezied normal adult dogs). A pool of human serum was taken as reference (Sm = 1 U/ml).
R M, Schimpff, M, Donnadieu, J C, Glasinovic, J M, Warnet, F, Girard   +4 more
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Purification of bovine somatomedin

Biochemical and Biophysical Research Communications, 1975
Abstract A procedure for the purification of bovine somatomedin (SM 4 ) is presented. The purification scheme utilizes ultrafiltration through membranes of nominal mol. wt. cutoffs, molecular sieve chromatography and finally iso-electric focusing.
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Nutrition, somatomedins, and the brain

Metabolism, 1986
Conditions of decreased nutrient supply (malnutrition) and/or decreased nutrient utilization (diabetes) are attended by impairment of growth despite an increase in circulating levels of growth hormone (GH). Growth involves the actions of somatomedins, circulating insulinlike polypeptides with anabolic effects on cartilage, fat, and muscle.
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[Somatomedins].

Wiener klinische Wochenschrift, 1987
Somatomedins are peptide hormones with insulin-like structure and effects. Their synthesis is governed by growth hormone. Somatomedins stimulate growth of cartilage tissue and other tissues. Synthesis of somatomedins occurs in various tissues, predominantly in the liver.
M B, Ranke, W, Blum, J R, Bierich
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Radioimmunoassay of Somatomedin B

1975
Publisher Summary This chapter provides an overview of radioimmunoassay of somatomedin B. The sensitivity of the assay permits the measurement of this factor in human plasma diluted 1:20,000 and in monkey plasma diluted 1:5000. Somatomedin B is not detected in many nonprimate plasmas diluted 1:20.
R S, Yalow, K, Hall, R, Luft
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Growth Hormone and Somatomedin

1974
Publisher Summary This chapter provides an overview of the growth hormone and somatomedin. It is well established that growth hormone in vivo promotes skeletal growth and protein synthesis. Growth hormone promotes protein synthesis by stimulating the appearance in the tissues of a secondary factor, sulfation factor or somatomedin, which transfers ...
K, Hall, R, Luft
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