Results 111 to 120 of about 122,837 (260)

Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Whereas biased agonism on the 5‐HT2A receptor has been ascribed to hallucinogenic properties of psychedelics, no information about biased inverse agonism on this receptor is available. In schizophrenia, increased 5‐HT2A receptor constitutive activity has been suggested, highlighting the therapeutic relevance of inverse ...
Itziar Muneta‐Arrate, Patricia Miranda‐Azpiazu, Igor Horrillo, Rebeca Diez‐Alarcia, J. Javier Meana   +4 more
wiley   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Factors Associated With Balance and Fear of Falling in Patients With Benign Paroxysmal Positional Vertigo: A Controlled Cross‐Sectional Study

Clinical Otolaryngology, Volume 50, Issue 3, Page 492-499, May 2025.
ABSTRACT Objectives The aim of this study is to evaluate the factors influencing balance and fear of falling (FOF) in patients with benign paroxysmal positional vertigo (BPPV). Design A controlled cross‐sectional study. Setting Single center study. Methods A total of 31 patients with BPPV and 30 controls were included in this cross‐sectional study. The
Dilek Baday‐Keskin, Mustafa Burak Taş, Nuray Bayar‐Muluk   +2 more
wiley   +1 more source

Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases

Cell Proliferation, EarlyView.
The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley   +1 more source

Accuracy of heartbeat perception is reflected in the amplitude of the heartbeat-evoked brain potential. [PDF]

, 2004
Ahern, Augustine, Aziz, Aziz, Bajwa, Bechara, Bennarroch, Berthoud, Bloch-Salisbury, Cameron, Carrillo-de-la-Pena, Cass, Covington, Critchley, Damasio, Damasio, Devrim, Dirlich, Dirlich, Ehlers, Ehlers, Fallen, Ferguson, Franssen, Furlong, Gratton, Hanamori, Hari, Hashimoto, Hillyard, Hjorth, Hobson, Hobson, Hollerbach, Hollerbach, Jaening, Jaening, Jones, Jones, Katkin, Kekoni, King, Knafelc, Leopold, Montoya, Montoya, Mussgay, Nakajima, Nieuwenhuys, Oppenheimer, Picton, Riordan, Rosen, Rosen, Schandry, Schandry, Schandry, Schandry, Schnitzler, Schnitzler, Shimojo, Tougas, Trejo, Webster, Weitkunat, Weitkunat, Weitkunat, Yoon   +67 more
core   +1 more source

Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near‐infrared spectroscopy: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 7, Page 875-891, July 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16286 Abstract Aim To map and critically appraise the literature on the feasibility and current use of functional near‐infrared spectroscopy (fNIRS) to assess cortical activity, functional connectivity, and neuroplasticity in individuals with cerebral palsy (CP).
Owais A. Khan, Simin Rahman, Kanishka Baduni, Christopher M. Modlesky   +3 more
wiley   +1 more source

The Burning Pain Transcriptome in the Mouse Primary Somatosensory Cortex. [PDF]

Int J Mol Sci
Erdei V, Mészár Z, Varga A.
europepmc   +1 more source

Lateralizing value of interictal epileptiform discharges and other parameters in hypothalamic hamartoma

Epilepsia, Volume 66, Issue 3, Page 662-673, March 2025.
Abstract Objective Hypothalamic hamartomas (HHs) are associated with pharmacoresistant epilepsy. Stereotactic radiofrequency thermocoagulation (SRT) shows promise as a disconnecting intervention. Although magnetic resonance imaging (MRI) is typically used to determine the attachment and intervention side, it presents challenges in cases of bilaterally ...
Friederike Niedermoser, Sarah M. Metzger, Kathrin Wagner, Peter C. Reinacher, Jan Schönberger, Julia Jacobs‐LeVan, Andreas Schulze‐Bonhage, Kerstin Alexandra Klotz   +7 more
wiley   +1 more source

GABAergic integration of transient and persistent neurons in the developing mouse somatosensory cortex. [PDF]

Front Cell Neurosci
Abusaada A, De Rosa F, Luhmann HJ, Kilb W, Sinning A.   +4 more
europepmc   +1 more source

Preferential superficial cortical layer activation during seizure propagation

Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.
Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya, Shinnosuke Shiono, Chengsan Sun, Edward Perez‐Reyes, Jaideep Kapur   +4 more
wiley   +1 more source