Results 141 to 150 of about 73,574 (320)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
British Journal of Pharmacology, EarlyView.Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
Cortical Somatosensory Evoked Potentials in Spine Surgery [PDF]
, 1985 Se Il Suk +4 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
Recovery of Evoked Potentials, Metabolic Activity and Behavior in a Mouse Model of Somatosensory Cortex Lesion: Role of the Neural Cell Adhesion Molecule (NCAM) [PDF]
, 2004 Edgardo Troncoso
openalex +1 more source
British Journal of Pharmacology, EarlyView.Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert +13 more
wiley +1 more source
Reduction of the acquisition time needed to obtain somatosensory evoked potentials by estimation of the required averaging sweep count by an algorithm [PDF]
Clemens Bothe +7 more
openalex +1 more source
Dermatomal somatosensory evoked potentials and cortical somatosensory evoked potentials assessment in congenital scoliosis [PDF]
, 2022 Zhenxing Zhang +6 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann +12 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2012 Objective To evaluate the efficacy of combined multiple intraoperative monitoring techniques including transcranial Doppler (TCD), indocyanine green angiography (ICGA) and neuroelectrophysiological monitoring consisting of somatosensory evoked potential (
Wei NI +5 more
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