Results 161 to 170 of about 199,096 (367)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Movement gating of beta/gamma oscillations involved in the N30 somatosensory evoked potential

Human Brain Mapping, 2009
A. Cebolla, C. De Saedeleer, A. Bengoetxea, F. Leurs, Costantino Balestra, P. d’Alcantara, E. Palmero-Soler, B. Dan, G. Cheron   +8 more
semanticscholar   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Multimodal evoked potentials are useful for the diagnosis of pediatric acute disseminated encephalomyelitis

BMC Pediatrics
Background The application of evoked potentials (EPs) to the diagnosis of acute disseminated encephalomyelitis (ADEM ) has not been investigated in detail.
Jing Liu, Mei Jin, Meijie Zhang, Yonggang Wang, Suzhen Sun   +4 more
doaj   +1 more source

Baseline Amplitude Ratios of Median Nerve Somatosensory Evoked Potentials: Clinical Implications During Carotid Endarterectomy [PDF]

Sven Malchow, Parisa Moll-Khosrawi, Kristen K Thomsen, Hans O. Pinnschmidt, Bernd Saugel, Christian Zöllner, Leonie Schulte‐Uentrop   +6 more
openalex   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Hilbert-Huang transform analysis of somatosensory and motor evoked potential for intraoperative neurophysiologic monitoring

, 2015
Chien-Chun Huang, Chao‐Kai Hu, Cherng‐Jyh Ke   +2 more
openalex   +2 more sources

Comparison of the Effects of Ischaemia on Early Components of the Somatosensory Evoked Potential in Brainstem, Thalamus, and Cerebral Cortex

Journal of Cerebral Blood Flow and Metabolism, 1984
N. Branston, A. Ladds, L. Symon, A. D. Wang   +3 more
semanticscholar   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

A reappraisal of "direction of scratch" test: using somatosensory evoked potentials and vibration perception. [PDF]

, 1992
Y Motoi, H Matsumoto, Y Kaneshige, Susumu Chiba   +3 more
openalex   +1 more source