Results 221 to 230 of about 309,846 (286)
GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases
MedComm, Volume 6, Issue 5, May 2025.Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie +10 more
wiley +1 more source
MedComm, Volume 6, Issue 5, May 2025.Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes +4 more
wiley +1 more source
An overview of the non‐procedural treatment options for peripheral neuropathic pain
Muscle &Nerve, Volume 71, Issue 5, Page 791-801, May 2025.Abstract Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non‐interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology,
Evan R. Zeldin +6 more
wiley +1 more source
Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease
Advanced Science, Volume 12, Issue 14, April 10, 2025.NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu +10 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 4, April 2025.cTMS can effectively improve the motor function of patients with stroke, with significant efficacy in balance and limb motor function. The therapeutic effect of cTMS was more pronounced when intervening in the subacute phase, and when the excitatory stimulation mode and moderate intensity (≤ 80% RMT) were used.
Yongxin Zhu +7 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 4, April 2025.We conducted a bibliometric analysis of mirror neuron research to examine global publication trends, methodological advancements, and emerging applications. Our findings highlight robust international collaborations, advanced imaging, neurotechnological and immersive technologies, and the translational potential of mirror neuron studies for ...
Yangyang Sun +5 more
wiley +1 more source
R‐Ras1 and R‐Ras2 regulate mature oligodendrocyte subpopulations
Glia, Volume 73, Issue 4, Page 701-719, April 2025.Main Points R‐Ras1 and R‐Ras2 are differentially expressed in mature oligodendrocytes subpopulations MOL1, MOL2 and MOL5/6. Lack of R‐Ras1 and R‐Ras2 produces an imbalance in mature oligodendrocyte subpopulation proportions. Abstract In the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid ...
Berta Alcover‐Sanchez +10 more
wiley +1 more source
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Somatosensory Evoked Potentials
The Journal of Bone and Joint Surgery-American Volume, 2000To The Editor: We are surprised by the claim made in the article "Dysfunction of the Spinal Cord During Spinal Arthrodesis for Scoliosis: Recommendations for Early Detection and Treatment. A Case Report" (80-A: 1679-1683, Nov. 1998), by Potenza et al., who state that "this is the first case to be reported in the English-language literature in which ...
B. A. Taylor, M. H. H. Noordeen
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Somatosensory Evoked Potentials
2011Intraoperative application of evoked potentials has evolved over the last thirty years, and somatosensory evoked potential (SSEP) monitoring is the method most commonly employed [1]. The ultimate goal of intraoperative SSEP monitoring is to ensure maintenance of neurologic integrity throughout a procedure with resultant improved outcome and decreased ...
Deborah A. Rusy, Aimee Becker
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Somatosensory evoked potentials
2019Somatosensory evoked potentials (SEPs) have been routinely used over the years to evaluate the somatosensory pathway and thereby supplement the diagnostic process when the history, neurologic examination, and imaging were not fully conclusive. The utilization of SEPs has become more popular in recent years despite the advance of imaging studies such as
Bachir Estephan, Iryna M. Muzyka
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